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• W2243339682 abstract "The natural spring period of transition into the ovulatory season in mares is characterized by increased follicular growth and the development of up to three successive dominant-size anovulatory follicles. These transitional follicles are severely underdeveloped, which has been attributed to low secretion of pituitary LH. It can therefore be hypothesized that administration of equine (e) LH during a follicular wave in early transitional mares will promote the development of ovulation-competent follicles. To test this hypothesis, 14 seasonally anovulatory mares were used starting in January in the Northern Hemisphere. Once a follicle >25mm was first identified (early transition) all follicles >15 mm were ablated by transvaginal ultrasound-guided follicle puncture. When the largest follicle of the ablation-induced wave reached >20mm, mares were given a subovulatory dose of a purified pituitary eLH fraction (0.25μg or 1μg eLH/kg, n=3/group) or saline (n=8) i.v. every 12 h and ovarian activity was monitored by ultrasound daily. Once the dominant follicle reached a diameter of >32mm, 3000 IU of hCG were administered to induce ovulation. Some of the mares were also used as ovulatory-season controls (n=5) during June and July. In these mares, follicles were ablated 10 days after ovulation followed by i.v administration of saline beginning when the largest follicle reached 20mm and injection of hCG once the follicle reached 32mm. During both seasons, blood samples were collected daily throughout the experiment for determination of plasma hormone levels by RIA. Data from transitional mares treated with the two different LH doses was not significantly different (P>0.8) and was therefore combined into a single LH-treated group (n=6) for analyses. Data was analyzed by repeated measures ANOVA and is reported as mean±SEM. Treatment with eLH during early transitional waves stimulated the growth of the dominant follicle (Group×Day, P=0.003) with a maximum diameter (day five of treatment) of 32.9±1.8 mm and 26.4±1.8 mm in eLH-treated and saline-treated mares, respectively (P<0.05). Follicle profiles were similar (P>0.9) between LH-treated transitional mares and ovulatory season controls. Profiles for the largest subordinate follicle were not affected (P>0.8) either by LH treatment during transition or by season. However, more follicles >10mm developed during the experimental period in saline-treated transitional mares (8.0±0.7 follicles) than in LH-treated transitional mares (5.2±0.6, P=0.008) or ovulatory season controls (5.2±0.6, P<0.001). Double-dominant follicles did not develop in any mare. Five eLH-treated mares were injected with hCG and three ovulated (60%), at an average of 56±8 h post-hCG. All ovulatory season controls ovulated and did so at a mean of 54±8.6 h after hCG, an interval similar to that in transitional mares (P>0.1). In addition, an increase in circulating progesterone levels occurred as expected in the three transitional mares that ovulated in response to hCG although this increase tended to be of lower magnitude than that after ovulation in ovulatory-season controls (Group×Day, P=0.08). These results are consistent with a causal effect of deficient circulating LH on reduced follicle development during the equine anovulatory season and demonstrate that exogenous eLH administration can stimulate the development of dominant follicles and facilitate early ovulations followed by the development of a functional CL. (poster)" @default.
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• W2243339682 date "2010-11-01" @default.
• W2243339682 modified "2023-10-16" @default.
• W2243339682 title "Effects of Exogenous Luteinizing Hormone on Development and Acquisition of Ovulatory Competence by Dominant Follicles During the Equine Anovulatory Season." @default.
• W2243339682 doi "https://doi.org/10.1093/biolreprod/83.s1.624" @default.
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