Matches in SemOpenAlex for { <https://semopenalex.org/work/W2243344362> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2243344362 endingPage "104" @default.
- W2243344362 startingPage "95" @default.
- W2243344362 abstract "The present study examined the location of the serotonin (5-HT)1A receptors mediating the induction of spontaneous tail-flicks (STFs) in the rat. Serotoninergic neurones were lesioned by i.c.v. administration of 5,7-dihydroxytryptamine, which depleted levels of 5-HT in the spinal cord and other CNS tissues by > 90% without affecting those of noradrenaline and dopamine. In lesioned rats, the ability of the 5-HT releasers, para-chloroamphetamine and methylenedioxymethamphetamine, to elicit STFs was abolished. In contrast, the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino)- tetralin (8-OH-DPAT), continued to evoke STFs. In fact, its effect was significantly enhanced in lesioned as compared with sham animals. In (nonlesioned) rats with catheters chronically implanted at the lumbar spinal level, intrathecal 8-OH-DPAT dose-dependently evoked STFs. The action of 8-OH-DPAT was extremely rapid, being maximal within 1 min of injection. Whereas the 5-HT1B/C agonist, TFMPP, the 5-HT1C/2 agonist, DOI, and the 5-HT3 agonist, m-chlorophenylbiguanide, failed to elicit STFs, the action of 8-OH-DPAT was mimicked by several other 5-HT1A agonists: S 14671, 5-MeODMT and lisuride. These also showed a time-course with a rapid onset. Further, the highly hydrophilic 5-HT1A agonist, 5-carboxyamidotryptamine, which fails to pass the blood-brain barrier, likewise dose-dependently elicited STFs upon direct lumbar administration. In contrast, administered onto the cervical spinal cord, it was completely ineffective. Systemic administration of the 5-HT1A antagonists, BMY 7378 or (-)-alprenolol, but not of the 5-HT1C/2 antagonist, ritanserin, nor of the 5-HT3 antagonist, ondansetron, blocked STFs elicited by lumbar administration of 8-OH-DPAT. Conversely, lumbar (but not cervical) administration of BMY 7378 and (-)-alprenolol dose-dependently blocked the action of systemic 8-OH-DPAT. These data demonstrate that STFs in the rat are mediated by 5-HT1A receptors postsynaptic to 5-HT neurones and localized in the lumbar spinal cord. Further, they support the concept of a relationship between STFs and mechanisms of primary sensory (nociceptive) processing." @default.
- W2243344362 created "2016-06-24" @default.
- W2243344362 creator A5012967009 @default.
- W2243344362 creator A5039339834 @default.
- W2243344362 creator A5041008066 @default.
- W2243344362 date "1993-01-01" @default.
- W2243344362 modified "2023-09-23" @default.
- W2243344362 title "5-HT1A receptors and the tail-flick response. IV. Spinally localized 5-HT1A receptors postsynaptic to serotoninergic neurones mediate spontaneous tail-flicks in the rat." @default.
- W2243344362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8423555" @default.
- W2243344362 hasPublicationYear "1993" @default.
- W2243344362 type Work @default.
- W2243344362 sameAs 2243344362 @default.
- W2243344362 citedByCount "15" @default.
- W2243344362 countsByYear W22433443622015 @default.
- W2243344362 countsByYear W22433443622016 @default.
- W2243344362 countsByYear W22433443622018 @default.
- W2243344362 crossrefType "journal-article" @default.
- W2243344362 hasAuthorship W2243344362A5012967009 @default.
- W2243344362 hasAuthorship W2243344362A5039339834 @default.
- W2243344362 hasAuthorship W2243344362A5041008066 @default.
- W2243344362 hasConcept C126322002 @default.
- W2243344362 hasConcept C134018914 @default.
- W2243344362 hasConcept C170493617 @default.
- W2243344362 hasConcept C185592680 @default.
- W2243344362 hasConcept C197341189 @default.
- W2243344362 hasConcept C2775864247 @default.
- W2243344362 hasConcept C2776120623 @default.
- W2243344362 hasConcept C2776238416 @default.
- W2243344362 hasConcept C2778938600 @default.
- W2243344362 hasConcept C2781093953 @default.
- W2243344362 hasConcept C2909992730 @default.
- W2243344362 hasConcept C37000724 @default.
- W2243344362 hasConcept C53910766 @default.
- W2243344362 hasConcept C71924100 @default.
- W2243344362 hasConcept C98274493 @default.
- W2243344362 hasConceptScore W2243344362C126322002 @default.
- W2243344362 hasConceptScore W2243344362C134018914 @default.
- W2243344362 hasConceptScore W2243344362C170493617 @default.
- W2243344362 hasConceptScore W2243344362C185592680 @default.
- W2243344362 hasConceptScore W2243344362C197341189 @default.
- W2243344362 hasConceptScore W2243344362C2775864247 @default.
- W2243344362 hasConceptScore W2243344362C2776120623 @default.
- W2243344362 hasConceptScore W2243344362C2776238416 @default.
- W2243344362 hasConceptScore W2243344362C2778938600 @default.
- W2243344362 hasConceptScore W2243344362C2781093953 @default.
- W2243344362 hasConceptScore W2243344362C2909992730 @default.
- W2243344362 hasConceptScore W2243344362C37000724 @default.
- W2243344362 hasConceptScore W2243344362C53910766 @default.
- W2243344362 hasConceptScore W2243344362C71924100 @default.
- W2243344362 hasConceptScore W2243344362C98274493 @default.
- W2243344362 hasIssue "1" @default.
- W2243344362 hasLocation W22433443621 @default.
- W2243344362 hasOpenAccess W2243344362 @default.
- W2243344362 hasPrimaryLocation W22433443621 @default.
- W2243344362 hasRelatedWork W1977605904 @default.
- W2243344362 hasRelatedWork W2013997031 @default.
- W2243344362 hasRelatedWork W2022725540 @default.
- W2243344362 hasRelatedWork W2038865265 @default.
- W2243344362 hasRelatedWork W2066247837 @default.
- W2243344362 hasRelatedWork W2160769306 @default.
- W2243344362 hasRelatedWork W2243344362 @default.
- W2243344362 hasRelatedWork W271579403 @default.
- W2243344362 hasRelatedWork W2789439376 @default.
- W2243344362 hasRelatedWork W70096153 @default.
- W2243344362 hasVolume "264" @default.
- W2243344362 isParatext "false" @default.
- W2243344362 isRetracted "false" @default.
- W2243344362 magId "2243344362" @default.
- W2243344362 workType "article" @default.