FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2243347490> ?p ?o ?g. }

• W2243347490 endingPage "e0142262" @default.
• W2243347490 startingPage "e0142262" @default.
• W2243347490 abstract "MicroRNAs (miRNAs) are non-coding RNAs of ~22 nucleotides in length that regulate gene expression by interfering with the stability and translation of mRNAs. Their expression is regulated during development, under a wide variety of stress conditions and in several pathological processes. In nature, animals often face feast or famine conditions. We observed that subjecting early L4 larvae from Caenorhabditis elegans to a 12-hr starvation period produced worms that are thinner and shorter than well-fed animals, with a decreased lipid accumulation, diminished progeny, reduced gonad size, and an increased lifespan. Our objective was to identify which of the 302 known miRNAs of C. elegans changed their expression under starvation conditions as compared to well-fed worms by means of deep sequencing in early L4 larvae. Our results indicate that 13 miRNAs (miR-34-3p, the family of miR-35-3p to miR-41-3p, miR-39-5p, miR-41-5p, miR-240-5p, miR-246-3p and miR-4813-5p) were upregulated, while 2 miRNAs (let-7-3p and miR-85-5p) were downregulated in 12-hr starved vs. well-fed early L4 larvae. Some of the predicted targets of the miRNAs that changed their expression in starvation conditions are involved in metabolic or developmental process. In particular, miRNAs of the miR-35 family were upregulated 6–20 fold upon starvation. Additionally, we showed that the expression of gld-1, important in oogenesis, a validated target of miR-35-3p, was downregulated when the expression of miR-35-3p was upregulated. The expression of another reported target, the cell cycle regulator lin-23, was unchanged during starvation. This study represents a starting point for a more comprehensive understanding of the role of miRNAs during starvation in C. elegans." @default.
• W2243347490 created "2016-06-24" @default.
• W2243347490 creator A5000413759 @default.
• W2243347490 creator A5005739673 @default.
• W2243347490 creator A5010594779 @default.
• W2243347490 creator A5014947740 @default.
• W2243347490 creator A5046334816 @default.
• W2243347490 creator A5065853818 @default.
• W2243347490 creator A5091810456 @default.
• W2243347490 date "2015-11-10" @default.
• W2243347490 modified "2023-10-11" @default.
• W2243347490 title "High-Throughput Profiling of Caenorhabditis elegans Starvation-Responsive microRNAs" @default.
• W2243347490 cites W1574375290 @default.
• W2243347490 cites W1599543703 @default.
• W2243347490 cites W1838268929 @default.
• W2243347490 cites W1861035294 @default.
• W2243347490 cites W1920303762 @default.
• W2243347490 cites W193388854 @default.
• W2243347490 cites W1954154760 @default.
• W2243347490 cites W1958284284 @default.
• W2243347490 cites W1966612206 @default.
• W2243347490 cites W1968631483 @default.
• W2243347490 cites W1972745320 @default.
• W2243347490 cites W1977055737 @default.
• W2243347490 cites W1977889799 @default.
• W2243347490 cites W1978337436 @default.
• W2243347490 cites W1979415389 @default.
• W2243347490 cites W1979565277 @default.
• W2243347490 cites W1983306001 @default.
• W2243347490 cites W1984007135 @default.
• W2243347490 cites W1987448390 @default.
• W2243347490 cites W1989768797 @default.
• W2243347490 cites W1991425207 @default.
• W2243347490 cites W1991840483 @default.
• W2243347490 cites W1993107878 @default.
• W2243347490 cites W1998819524 @default.
• W2243347490 cites W1999989614 @default.
• W2243347490 cites W2001940393 @default.
• W2243347490 cites W2003952411 @default.
• W2243347490 cites W2006751208 @default.
• W2243347490 cites W2007198184 @default.
• W2243347490 cites W2009550994 @default.
• W2243347490 cites W2010097127 @default.
• W2243347490 cites W2017994437 @default.
• W2243347490 cites W2020268185 @default.
• W2243347490 cites W2020454013 @default.
• W2243347490 cites W2022326327 @default.
• W2243347490 cites W2022987064 @default.
• W2243347490 cites W2026570544 @default.
• W2243347490 cites W2030812395 @default.
• W2243347490 cites W2031143868 @default.
• W2243347490 cites W2033167804 @default.
• W2243347490 cites W2033583810 @default.
• W2243347490 cites W2040648064 @default.
• W2243347490 cites W2041075531 @default.
• W2243347490 cites W2041680143 @default.
• W2243347490 cites W2042474311 @default.
• W2243347490 cites W2042986568 @default.
• W2243347490 cites W2044803581 @default.
• W2243347490 cites W2044832480 @default.
• W2243347490 cites W2046387002 @default.
• W2243347490 cites W2051370920 @default.
• W2243347490 cites W2051936739 @default.
• W2243347490 cites W2052210687 @default.
• W2243347490 cites W2057756644 @default.
• W2243347490 cites W2059712176 @default.
• W2243347490 cites W2066787182 @default.
• W2243347490 cites W2069356649 @default.
• W2243347490 cites W2070144316 @default.
• W2243347490 cites W2071221374 @default.
• W2243347490 cites W2077327925 @default.
• W2243347490 cites W2083822954 @default.
• W2243347490 cites W2088009035 @default.
• W2243347490 cites W2088966640 @default.
• W2243347490 cites W2089914297 @default.
• W2243347490 cites W2098727578 @default.
• W2243347490 cites W2100555999 @default.
• W2243347490 cites W2100932663 @default.
• W2243347490 cites W2101650741 @default.
• W2243347490 cites W2107420367 @default.
• W2243347490 cites W2108244474 @default.
• W2243347490 cites W2109816088 @default.
• W2243347490 cites W2110192919 @default.
• W2243347490 cites W2114037525 @default.
• W2243347490 cites W2114104545 @default.
• W2243347490 cites W2122855685 @default.
• W2243347490 cites W2123188122 @default.
• W2243347490 cites W2124985265 @default.
• W2243347490 cites W2125596551 @default.
• W2243347490 cites W2131397861 @default.
• W2243347490 cites W2133968430 @default.
• W2243347490 cites W2139956822 @default.
• W2243347490 cites W2141311279 @default.
• W2243347490 cites W2141500037 @default.
• W2243347490 cites W2141939436 @default.
• W2243347490 cites W2142398748 @default.
• W2243347490 cites W2144005841 @default.
• W2243347490 cites W2144038313 @default.

• next