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- W2243366186 abstract "This paper report on the neuropathological examinations studies of a 74 year-old woman with illness of Alzheimer’s (AD) and of her 47 year-old non-demented daughter. The mother’s brain showed fully developed pathological changes of AD. By constrast, the brain of daughter’s revealed only perineural depositions of diffuse amyloid in cerebral cortex and striking abnormalities of the endosomal-lisosomal system, without neurofibrilary, glial, or microglial changes. These observations suggest that the amyloid depositions and the endosomal-lisosomal changes are early events in the late onset AD and that they may precede the onset of dementia by several decades. These findigns give a newly information about diagnostic value in terms of physiopathology." @default.
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- W2243366186 date "2006-01-01" @default.
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- W2243366186 title "Lesiones precoces en la enfermedad de Alzheimer" @default.
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