FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2243387308> ?p ?o ?g. }

• W2243387308 endingPage "1111" @default.
• W2243387308 startingPage "1102" @default.
• W2243387308 abstract "LOH at chromosome arms 3p, 9p, 11q, and 17p are well-established oncogenetic aberrations in oral precancerous lesions and promising biomarkers to monitor the development of oral cancer. Noninvasive LOH screening of brushed oral cells is a preferable method for precancer detection in patients at increased risk for head and neck squamous cell carcinoma (HNSCC), such as patients with Fanconi anemia. We determined the prevalence of LOH in brushed samples of the oral epithelium of 141 patients with Fanconi anemia and 144 aged subjects, and studied the association between LOH and HNSCC. LOH was present in 14 (9.9%) nontransplanted patients with Fanconi anemia, whereas LOH was not detected in a low-risk group (n = 50, >58 years, nonsmoking/nonalcohol history) and a group with somewhat increased HNSCC risk (n = 94, >58 years, heavy smoking/excessive alcohol use); Fisher exact test, P = 0.023 and P = 0.001, respectively. Most frequent genetic alteration was LOH at 9p. Age was a significant predictor of LOH (OR, 1.13, P = 0.001). Five patients with Fanconi anemia developed HNSCC during the study at a median age of 39.6 years (range, 24.8-53.7). LOH was significantly associated with HNSCC (Fisher exact test, P = 0.000). Unexpectedly, the LOH assay could not be used for transplanted patients with Fanconi anemia because donor DNA in brushed oral epithelium, most likely from donor leukocytes present in the oral cavity, disturbed the analysis. Noninvasive screening using a LOH assay on brushed samples of the oral epithelium has a promising outlook in patients with Fanconi anemia. However, assays need to be adapted in case of stem cell transplantation, because of contaminating donor DNA." @default.
• W2243387308 created "2016-06-24" @default.
• W2243387308 creator A5005400826 @default.
• W2243387308 creator A5026177049 @default.
• W2243387308 creator A5027249831 @default.
• W2243387308 creator A5038008573 @default.
• W2243387308 creator A5043095023 @default.
• W2243387308 creator A5057671126 @default.
• W2243387308 creator A5062808434 @default.
• W2243387308 creator A5065170251 @default.
• W2243387308 creator A5070012126 @default.
• W2243387308 creator A5072446531 @default.
• W2243387308 creator A5077403448 @default.
• W2243387308 date "2015-11-01" @default.
• W2243387308 modified "2023-10-12" @default.
• W2243387308 title "Noninvasive Molecular Screening for Oral Precancer in Fanconi Anemia Patients" @default.
• W2243387308 cites W1856235061 @default.
• W2243387308 cites W1971231849 @default.
• W2243387308 cites W1986030260 @default.
• W2243387308 cites W1987286103 @default.
• W2243387308 cites W1989566285 @default.
• W2243387308 cites W1990956554 @default.
• W2243387308 cites W1991374176 @default.
• W2243387308 cites W1991949008 @default.
• W2243387308 cites W1997148030 @default.
• W2243387308 cites W1997537079 @default.
• W2243387308 cites W2001935713 @default.
• W2243387308 cites W2003252913 @default.
• W2243387308 cites W2011291904 @default.
• W2243387308 cites W2038700124 @default.
• W2243387308 cites W2041792235 @default.
• W2243387308 cites W2049689768 @default.
• W2243387308 cites W2049871469 @default.
• W2243387308 cites W2062073391 @default.
• W2243387308 cites W2066808172 @default.
• W2243387308 cites W2084336300 @default.
• W2243387308 cites W2086698289 @default.
• W2243387308 cites W2091698428 @default.
• W2243387308 cites W2091753311 @default.
• W2243387308 cites W2093553704 @default.
• W2243387308 cites W2099590148 @default.
• W2243387308 cites W2099837074 @default.
• W2243387308 cites W2101531342 @default.
• W2243387308 cites W2103472185 @default.
• W2243387308 cites W2119574468 @default.
• W2243387308 cites W2131657653 @default.
• W2243387308 cites W2137273906 @default.
• W2243387308 cites W2139599388 @default.
• W2243387308 cites W2147774152 @default.
• W2243387308 cites W2156548406 @default.
• W2243387308 cites W2156823154 @default.
• W2243387308 cites W2166957473 @default.
• W2243387308 cites W2168104423 @default.
• W2243387308 cites W2171776496 @default.
• W2243387308 cites W2171805075 @default.
• W2243387308 cites W2269582226 @default.
• W2243387308 cites W2808137945 @default.
• W2243387308 doi "https://doi.org/10.1158/1940-6207.capr-15-0220" @default.
• W2243387308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26276748" @default.
• W2243387308 hasPublicationYear "2015" @default.
• W2243387308 type Work @default.
• W2243387308 sameAs 2243387308 @default.
• W2243387308 citedByCount "18" @default.
• W2243387308 countsByYear W22433873082016 @default.
• W2243387308 countsByYear W22433873082018 @default.
• W2243387308 countsByYear W22433873082019 @default.
• W2243387308 countsByYear W22433873082020 @default.
• W2243387308 countsByYear W22433873082021 @default.
• W2243387308 countsByYear W22433873082022 @default.
• W2243387308 countsByYear W22433873082023 @default.
• W2243387308 crossrefType "journal-article" @default.
• W2243387308 hasAuthorship W2243387308A5005400826 @default.
• W2243387308 hasAuthorship W2243387308A5026177049 @default.
• W2243387308 hasAuthorship W2243387308A5027249831 @default.
• W2243387308 hasAuthorship W2243387308A5038008573 @default.
• W2243387308 hasAuthorship W2243387308A5043095023 @default.
• W2243387308 hasAuthorship W2243387308A5057671126 @default.
• W2243387308 hasAuthorship W2243387308A5062808434 @default.
• W2243387308 hasAuthorship W2243387308A5065170251 @default.
• W2243387308 hasAuthorship W2243387308A5070012126 @default.
• W2243387308 hasAuthorship W2243387308A5072446531 @default.
• W2243387308 hasAuthorship W2243387308A5077403448 @default.
• W2243387308 hasBestOaLocation W22433873081 @default.
• W2243387308 hasConcept C121608353 @default.
• W2243387308 hasConcept C126322002 @default.
• W2243387308 hasConcept C134935766 @default.
• W2243387308 hasConcept C142724271 @default.
• W2243387308 hasConcept C143998085 @default.
• W2243387308 hasConcept C191093355 @default.
• W2243387308 hasConcept C2776530083 @default.
• W2243387308 hasConcept C2776833033 @default.
• W2243387308 hasConcept C2778124228 @default.
• W2243387308 hasConcept C2778248108 @default.
• W2243387308 hasConcept C502942594 @default.
• W2243387308 hasConcept C54355233 @default.
• W2243387308 hasConcept C552990157 @default.
• W2243387308 hasConcept C71924100 @default.
• W2243387308 hasConcept C86803240 @default.

• next