FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2243393118> ?p ?o ?g. }

• W2243393118 endingPage "1867" @default.
• W2243393118 startingPage "1858" @default.
• W2243393118 abstract "We treated 64 patients with metastatic melanoma using a melanoma vaccine preceded by low-dose cyclophosphamide (CY), and monitored immunologic effects and antitumor activity. On day 0, the patients were given CY 300 mg/m2 intravenously. Three days later, they were injected intradermally with vaccine consisting of 10 to 25 x 10(6) autologous, enzymatically dissociated, cryopreserved, irradiated (25 Gy) tumor cells mixed with bacillus Calmette-Guérin (BCG). This treatment sequence was repeated every 28 days. Of 40 assessable patients with measurable metastases, five had responses, four complete and one partial, with a median duration of 10 months (7 to 84+ months). In six additional patients, we observed an antitumor response that seems to be peculiar to this vaccine therapy: the regression of metastatic lesions that appeared after the immunotherapy was begun. Delayed-type hypersensitivity (DTH) to autologous, mechanically dissociated melanoma cells that had not been exposed to extraneous antigens, such as enzymes or fetal calf serum, increased significantly following immunotherapy (day 0 v day 49, P less than .001; day 0 v day 161, P less than .001; day 0 v day 217, P = .021). Antitumor responses to the vaccine were strongly associated with DTH, as indicated by three observations: (1) eight of 10 patients who exhibited tumor regression had positive DTH, (2) in postsurgical adjuvant patients, there was a highly significant linear relationship (P less than .001) between the intensity of DTH to autologous melanoma cells and the time to recurrence of tumor, and (3) nine patients who developed DTH to the autologous melanoma cells in their original vaccine developed new metastases that failed to elicit DTH or elicited a much smaller response. In three cases, we were able to excise regressing tumors for histologic examination; such tumors were characterized by an intense infiltration of lymphocytes. This demonstration that an immune response to melanoma-associated antigens can be elicited in cancer-bearing patients provides some basis for optimism about the prospects for developing active immunotherapy that has practical therapeutic value." @default.
• W2243393118 created "2016-06-24" @default.
• W2243393118 creator A5012659487 @default.
• W2243393118 creator A5016752653 @default.
• W2243393118 creator A5018707165 @default.
• W2243393118 creator A5045802455 @default.
• W2243393118 date "1990-11-01" @default.
• W2243393118 modified "2023-09-25" @default.
• W2243393118 title "Treatment of metastatic melanoma with an autologous tumor-cell vaccine: clinical and immunologic results in 64 patients." @default.
• W2243393118 cites W1484465820 @default.
• W2243393118 cites W1533446346 @default.
• W2243393118 cites W1549875301 @default.
• W2243393118 cites W1576953154 @default.
• W2243393118 cites W1587942381 @default.
• W2243393118 cites W1607021142 @default.
• W2243393118 cites W1678349295 @default.
• W2243393118 cites W1893357085 @default.
• W2243393118 cites W1977476969 @default.
• W2243393118 cites W1982638987 @default.
• W2243393118 cites W1984183901 @default.
• W2243393118 cites W2047203592 @default.
• W2243393118 cites W2074253126 @default.
• W2243393118 cites W2133514770 @default.
• W2243393118 cites W2158847590 @default.
• W2243393118 cites W2159707304 @default.
• W2243393118 cites W2163401797 @default.
• W2243393118 cites W2262779158 @default.
• W2243393118 cites W2407920764 @default.
• W2243393118 cites W2423045229 @default.
• W2243393118 doi "https://doi.org/10.1200/jco.1990.8.11.1858" @default.
• W2243393118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2230873" @default.
• W2243393118 hasPublicationYear "1990" @default.
• W2243393118 type Work @default.
• W2243393118 sameAs 2243393118 @default.
• W2243393118 citedByCount "289" @default.
• W2243393118 countsByYear W22433931182012 @default.
• W2243393118 countsByYear W22433931182013 @default.
• W2243393118 countsByYear W22433931182014 @default.
• W2243393118 countsByYear W22433931182015 @default.
• W2243393118 countsByYear W22433931182016 @default.
• W2243393118 countsByYear W22433931182017 @default.
• W2243393118 countsByYear W22433931182018 @default.
• W2243393118 countsByYear W22433931182019 @default.
• W2243393118 countsByYear W22433931182020 @default.
• W2243393118 countsByYear W22433931182021 @default.
• W2243393118 countsByYear W22433931182022 @default.
• W2243393118 countsByYear W22433931182023 @default.
• W2243393118 crossrefType "journal-article" @default.
• W2243393118 hasAuthorship W2243393118A5012659487 @default.
• W2243393118 hasAuthorship W2243393118A5016752653 @default.
• W2243393118 hasAuthorship W2243393118A5018707165 @default.
• W2243393118 hasAuthorship W2243393118A5045802455 @default.
• W2243393118 hasConcept C121608353 @default.
• W2243393118 hasConcept C126322002 @default.
• W2243393118 hasConcept C147483822 @default.
• W2243393118 hasConcept C203014093 @default.
• W2243393118 hasConcept C2776624504 @default.
• W2243393118 hasConcept C2776694085 @default.
• W2243393118 hasConcept C2776755627 @default.
• W2243393118 hasConcept C2777658100 @default.
• W2243393118 hasConcept C2777701055 @default.
• W2243393118 hasConcept C2777863537 @default.
• W2243393118 hasConcept C502942594 @default.
• W2243393118 hasConcept C71924100 @default.
• W2243393118 hasConcept C90924648 @default.
• W2243393118 hasConceptScore W2243393118C121608353 @default.
• W2243393118 hasConceptScore W2243393118C126322002 @default.
• W2243393118 hasConceptScore W2243393118C147483822 @default.
• W2243393118 hasConceptScore W2243393118C203014093 @default.
• W2243393118 hasConceptScore W2243393118C2776624504 @default.
• W2243393118 hasConceptScore W2243393118C2776694085 @default.
• W2243393118 hasConceptScore W2243393118C2776755627 @default.
• W2243393118 hasConceptScore W2243393118C2777658100 @default.
• W2243393118 hasConceptScore W2243393118C2777701055 @default.
• W2243393118 hasConceptScore W2243393118C2777863537 @default.
• W2243393118 hasConceptScore W2243393118C502942594 @default.
• W2243393118 hasConceptScore W2243393118C71924100 @default.
• W2243393118 hasConceptScore W2243393118C90924648 @default.
• W2243393118 hasIssue "11" @default.
• W2243393118 hasLocation W22433931181 @default.
• W2243393118 hasLocation W22433931182 @default.
• W2243393118 hasOpenAccess W2243393118 @default.
• W2243393118 hasPrimaryLocation W22433931181 @default.
• W2243393118 hasRelatedWork W1974496092 @default.
• W2243393118 hasRelatedWork W2000609640 @default.
• W2243393118 hasRelatedWork W2033998433 @default.
• W2243393118 hasRelatedWork W2289813745 @default.
• W2243393118 hasRelatedWork W2397019724 @default.
• W2243393118 hasRelatedWork W2398879668 @default.
• W2243393118 hasRelatedWork W2417257223 @default.
• W2243393118 hasRelatedWork W2468367074 @default.
• W2243393118 hasRelatedWork W2427250343 @default.
• W2243393118 hasRelatedWork W2612645077 @default.
• W2243393118 hasVolume "8" @default.
• W2243393118 isParatext "false" @default.
• W2243393118 isRetracted "false" @default.
• W2243393118 magId "2243393118" @default.
• W2243393118 workType "article" @default.