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• W2243394267 abstract "Detailed and innovative analysis of gene regulatory network structures may reveal novel insights to biological mechanisms. Here we study how gene regulatory network in Saccharomyces cerevisiae can differ under aerobic and anaerobic conditions. To achieve this, we discretized the gene expression profiles and calculated the self-entropy of down- and upregulation of gene expression as well as joint entropy. Based on these quantities the uncertainty coefficient was calculated for each gene triplet, following which, separate gene logic networks were constructed for the aerobic and anaerobic conditions. Four structural parameters such as average degree, average clustering coefficient, average shortest path, and average betweenness were used to compare the structure of the corresponding aerobic and anaerobic logic networks. Five genes were identified to be putative key components of the two energy metabolisms. Furthermore, community analysis using the Newman fast algorithm revealed two significant communities for the aerobic but only one for the anaerobic network. David Gene Functional Classification suggests that, under aerobic conditions, one such community reflects the cell cycle and cell replication, while the other one is linked to the mitochondrial respiratory chain function." @default.
• W2243394267 created "2016-06-24" @default.
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• W2243394267 date "2015-01-01" @default.
• W2243394267 modified "2023-10-15" @default.
• W2243394267 title "Modeling Gene Networks inSaccharomyces cerevisiaeBased on Gene Expression Profiles" @default.
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• W2243394267 doi "https://doi.org/10.1155/2015/621264" @default.
• W2243394267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4709922" @default.
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