Matches in SemOpenAlex for { <https://semopenalex.org/work/W2243395523> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2243395523 endingPage "613" @default.
- W2243395523 startingPage "611" @default.
- W2243395523 abstract "Objective To investigate the mechanism of action of JAK/STAT signaling pathways in the lung injury of experimental severe acute pancreatitis(SAP).Methods The rat model of SAP was reproduced by retrograde injection of 4% sodium taurocholate into the biliopancreatic duct.Thirty-two male SD rats were randomly assigned into 4 groups(8 each): normal control group(NC),SAP 6h,12h and 18h groups.The level of serum amylase(AMY) was measured dynamically.The pathological changes in pancreas and lung were observed under the light microscope,and the wet/dry weight ratios of lung were evaluated.The concentrations of IL-6 and IL-18 were determined by ELISA,and the expressions of JAK2 and STAT3 protein in lung were determined by Western blotting.Results Compared with NC group,serum level of AMY increased significantly in SAP groups(P < 0.01),and the pancreas and lung injuries under the light microscope were gradually aggravated with disease progression.The wet/dry weight ratio of lung in SAP groups increased significantly compared with that in NC group(P < 0.01).The serum concentrations of IL-6,IL-18 in the SAP groups increased significantly compared with those in NC group(P < 0.01).The concentrations of JAK2 and STAT3 protein in SAP groups increased significantly compared with that in NC group(P < 0.01) and reached the peak in 12-18 hours.Conclusion Activation of JAK2/STAT3 signaling pathways may induce the over-expressions of IL-6 and IL-18,and aggravate the inflammatory reaction and lung injury induced by SAP." @default.
- W2243395523 created "2016-06-24" @default.
- W2243395523 creator A5002337475 @default.
- W2243395523 creator A5008863936 @default.
- W2243395523 creator A5012766373 @default.
- W2243395523 creator A5063018174 @default.
- W2243395523 creator A5076423081 @default.
- W2243395523 creator A5078192755 @default.
- W2243395523 creator A5085050167 @default.
- W2243395523 date "2011-06-01" @default.
- W2243395523 modified "2023-10-17" @default.
- W2243395523 title "The role of JAK2/STAT3 signaling pathway in the lung injury rat with severe acute pancreatitis" @default.
- W2243395523 hasPublicationYear "2011" @default.
- W2243395523 type Work @default.
- W2243395523 sameAs 2243395523 @default.
- W2243395523 citedByCount "1" @default.
- W2243395523 countsByYear W22433955232020 @default.
- W2243395523 crossrefType "journal-article" @default.
- W2243395523 hasAuthorship W2243395523A5002337475 @default.
- W2243395523 hasAuthorship W2243395523A5008863936 @default.
- W2243395523 hasAuthorship W2243395523A5012766373 @default.
- W2243395523 hasAuthorship W2243395523A5063018174 @default.
- W2243395523 hasAuthorship W2243395523A5076423081 @default.
- W2243395523 hasAuthorship W2243395523A5078192755 @default.
- W2243395523 hasAuthorship W2243395523A5085050167 @default.
- W2243395523 hasConcept C126322002 @default.
- W2243395523 hasConcept C134018914 @default.
- W2243395523 hasConcept C142724271 @default.
- W2243395523 hasConcept C185592680 @default.
- W2243395523 hasConcept C207886595 @default.
- W2243395523 hasConcept C2775967933 @default.
- W2243395523 hasConcept C2776670229 @default.
- W2243395523 hasConcept C2777714996 @default.
- W2243395523 hasConcept C2778764654 @default.
- W2243395523 hasConcept C2778923194 @default.
- W2243395523 hasConcept C55493867 @default.
- W2243395523 hasConcept C62478195 @default.
- W2243395523 hasConcept C71924100 @default.
- W2243395523 hasConceptScore W2243395523C126322002 @default.
- W2243395523 hasConceptScore W2243395523C134018914 @default.
- W2243395523 hasConceptScore W2243395523C142724271 @default.
- W2243395523 hasConceptScore W2243395523C185592680 @default.
- W2243395523 hasConceptScore W2243395523C207886595 @default.
- W2243395523 hasConceptScore W2243395523C2775967933 @default.
- W2243395523 hasConceptScore W2243395523C2776670229 @default.
- W2243395523 hasConceptScore W2243395523C2777714996 @default.
- W2243395523 hasConceptScore W2243395523C2778764654 @default.
- W2243395523 hasConceptScore W2243395523C2778923194 @default.
- W2243395523 hasConceptScore W2243395523C55493867 @default.
- W2243395523 hasConceptScore W2243395523C62478195 @default.
- W2243395523 hasConceptScore W2243395523C71924100 @default.
- W2243395523 hasIssue "6" @default.
- W2243395523 hasLocation W22433955231 @default.
- W2243395523 hasOpenAccess W2243395523 @default.
- W2243395523 hasPrimaryLocation W22433955231 @default.
- W2243395523 hasRelatedWork W2098283954 @default.
- W2243395523 hasRelatedWork W2244101049 @default.
- W2243395523 hasRelatedWork W2347896926 @default.
- W2243395523 hasRelatedWork W2348670767 @default.
- W2243395523 hasRelatedWork W2354580871 @default.
- W2243395523 hasRelatedWork W2356871460 @default.
- W2243395523 hasRelatedWork W2357563652 @default.
- W2243395523 hasRelatedWork W2360766434 @default.
- W2243395523 hasRelatedWork W2360814625 @default.
- W2243395523 hasRelatedWork W2367742639 @default.
- W2243395523 hasRelatedWork W2369570540 @default.
- W2243395523 hasRelatedWork W2383309044 @default.
- W2243395523 hasRelatedWork W2387752379 @default.
- W2243395523 hasRelatedWork W2389621251 @default.
- W2243395523 hasRelatedWork W2394254582 @default.
- W2243395523 hasRelatedWork W2774093552 @default.
- W2243395523 hasRelatedWork W2944415136 @default.
- W2243395523 hasRelatedWork W3024007827 @default.
- W2243395523 hasRelatedWork W3028756521 @default.
- W2243395523 hasRelatedWork W3032755322 @default.
- W2243395523 hasVolume "36" @default.
- W2243395523 isParatext "false" @default.
- W2243395523 isRetracted "false" @default.
- W2243395523 magId "2243395523" @default.
- W2243395523 workType "article" @default.