FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2243447040> ?p ?o ?g. }

• W2243447040 endingPage "127" @default.
• W2243447040 startingPage "121" @default.
• W2243447040 abstract "Biotransformation of danazol (1) (17β-hydroxy-17α-pregna-2,4-dien-20-yno-[2,3-d]-isoxazole) with Cunninghamella blakesleeana yielded three new metabolites 2–4 and a known metabolite 5. These metabolites were identified as 14β,17β-dihydroxy-2-(hydroxymethyl)-17α-pregn-4-en-20-yn-3-one (2), 1α,17β-dihydroxy-17α-pregna-2,4-dien-20-yno-[2,3-d]-isoxazole (3), 6β,17β-dihydroxy-17α-pregna-2,4-dien-20-yno-[2,3-d]-isoxazole (4), and 17β-hydroxy-2-(hydroxymethyl)-17α-pregn-1,4-dien-20-yn-3-one (5). Danazol (1) and its derivatives were evaluated against cervical cancer cell line (HeLa). Compound 1 showed a potent cytotoxicity with IC50 = 0.283 ± 0.013 μM, as compared to doxorubicin (IC50 = 0.506 ± 0.015 μM), where compound 3 was also found to be significantly active with IC50 = 13.427 ± 0.819 μM." @default.
• W2243447040 created "2016-06-24" @default.
• W2243447040 creator A5020493795 @default.
• W2243447040 creator A5029026806 @default.
• W2243447040 creator A5040577138 @default.
• W2243447040 creator A5053156107 @default.
• W2243447040 creator A5067965839 @default.
• W2243447040 creator A5082422770 @default.
• W2243447040 creator A5084710214 @default.
• W2243447040 date "2016-01-01" @default.
• W2243447040 modified "2023-09-25" @default.
• W2243447040 title "Microbial transformation of danazol with Cunninghamella blakesleeana and anti-cancer activity of danazol and its transformed products" @default.
• W2243447040 cites W170259557 @default.
• W2243447040 cites W1824628919 @default.
• W2243447040 cites W1964433907 @default.
• W2243447040 cites W1965185645 @default.
• W2243447040 cites W1985480129 @default.
• W2243447040 cites W2004218701 @default.
• W2243447040 cites W2006434892 @default.
• W2243447040 cites W2007411634 @default.
• W2243447040 cites W2012797355 @default.
• W2243447040 cites W2034142594 @default.
• W2243447040 cites W2044953508 @default.
• W2243447040 cites W2053246551 @default.
• W2243447040 cites W2053999425 @default.
• W2243447040 cites W2060873899 @default.
• W2243447040 cites W2061482307 @default.
• W2243447040 cites W2067482629 @default.
• W2243447040 cites W2080262933 @default.
• W2243447040 cites W2112338986 @default.
• W2243447040 cites W2133003338 @default.
• W2243447040 cites W2165521731 @default.
• W2243447040 cites W2283792817 @default.
• W2243447040 cites W2410511953 @default.
• W2243447040 cites W72891148 @default.
• W2243447040 doi "https://doi.org/10.1016/j.steroids.2015.11.010" @default.
• W2243447040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26666360" @default.
• W2243447040 hasPublicationYear "2016" @default.
• W2243447040 type Work @default.
• W2243447040 sameAs 2243447040 @default.
• W2243447040 citedByCount "10" @default.
• W2243447040 countsByYear W22434470402017 @default.
• W2243447040 countsByYear W22434470402018 @default.
• W2243447040 countsByYear W22434470402019 @default.
• W2243447040 countsByYear W22434470402020 @default.
• W2243447040 countsByYear W22434470402021 @default.
• W2243447040 countsByYear W22434470402022 @default.
• W2243447040 crossrefType "journal-article" @default.
• W2243447040 hasAuthorship W2243447040A5020493795 @default.
• W2243447040 hasAuthorship W2243447040A5029026806 @default.
• W2243447040 hasAuthorship W2243447040A5040577138 @default.
• W2243447040 hasAuthorship W2243447040A5053156107 @default.
• W2243447040 hasAuthorship W2243447040A5067965839 @default.
• W2243447040 hasAuthorship W2243447040A5082422770 @default.
• W2243447040 hasAuthorship W2243447040A5084710214 @default.
• W2243447040 hasConcept C109316439 @default.
• W2243447040 hasConcept C126322002 @default.
• W2243447040 hasConcept C181199279 @default.
• W2243447040 hasConcept C185592680 @default.
• W2243447040 hasConcept C202751555 @default.
• W2243447040 hasConcept C2777366897 @default.
• W2243447040 hasConcept C2777416354 @default.
• W2243447040 hasConcept C2777477808 @default.
• W2243447040 hasConcept C2777752497 @default.
• W2243447040 hasConcept C2779522080 @default.
• W2243447040 hasConcept C2780591741 @default.
• W2243447040 hasConcept C2780902042 @default.
• W2243447040 hasConcept C2781269603 @default.
• W2243447040 hasConcept C27881333 @default.
• W2243447040 hasConcept C55493867 @default.
• W2243447040 hasConcept C71240020 @default.
• W2243447040 hasConcept C71315377 @default.
• W2243447040 hasConcept C71924100 @default.
• W2243447040 hasConceptScore W2243447040C109316439 @default.
• W2243447040 hasConceptScore W2243447040C126322002 @default.
• W2243447040 hasConceptScore W2243447040C181199279 @default.
• W2243447040 hasConceptScore W2243447040C185592680 @default.
• W2243447040 hasConceptScore W2243447040C202751555 @default.
• W2243447040 hasConceptScore W2243447040C2777366897 @default.
• W2243447040 hasConceptScore W2243447040C2777416354 @default.
• W2243447040 hasConceptScore W2243447040C2777477808 @default.
• W2243447040 hasConceptScore W2243447040C2777752497 @default.
• W2243447040 hasConceptScore W2243447040C2779522080 @default.
• W2243447040 hasConceptScore W2243447040C2780591741 @default.
• W2243447040 hasConceptScore W2243447040C2780902042 @default.
• W2243447040 hasConceptScore W2243447040C2781269603 @default.
• W2243447040 hasConceptScore W2243447040C27881333 @default.
• W2243447040 hasConceptScore W2243447040C55493867 @default.
• W2243447040 hasConceptScore W2243447040C71240020 @default.
• W2243447040 hasConceptScore W2243447040C71315377 @default.
• W2243447040 hasConceptScore W2243447040C71924100 @default.
• W2243447040 hasFunder F4320309999 @default.
• W2243447040 hasLocation W22434470401 @default.
• W2243447040 hasLocation W22434470402 @default.
• W2243447040 hasOpenAccess W2243447040 @default.
• W2243447040 hasPrimaryLocation W22434470401 @default.
• W2243447040 hasRelatedWork W1872497053 @default.
• W2243447040 hasRelatedWork W2012181830 @default.

• next