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- W224364559 abstract "Temporal constraints play an important role in the specification and implementation of clinical trial protocols, and subsequently, in the querying of the generated trial data. Protocols specify a temporal schedule of clinical trial activities such as tests, procedures, and medications. The schedule includes temporal constraints on the sequence of these activities, on their duration, and on potential cycles. In this paper, we present our approach to formally represent temporal constraints found in clinical trials. We have identified a representative set of temporal constraints found in protocols to study immune tolerance. Our research group has developed a temporal constraint ontology that allows us to formulate the temporal constraints to the extent required to support clinical trials management. We use this ontology to provide temporal annotation of clinical activities in an encoded clinical trial protocol. We have developed a temporal model that represents time-stamped data and facilitates interval-based temporal operations on the data. Using semantic web technologies, we are building a knowledge-based framework that integrates the temporal constraint ontology with the temporal model to support queries on clinical trial data. Using our approach, we can formally specify temporal constraints, and reason with the temporal knowledge to support management of clinical trials." @default.
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- W224364559 date "2008-01-01" @default.
- W224364559 modified "2023-09-23" @default.
- W224364559 title "AN ONTOLOGICAL APPROACH TO REPRESENTING AND REASONING WITH TEMPORAL CONSTRAINTS IN CLINICAL TRIAL PROTOCOLS" @default.
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- W224364559 doi "https://doi.org/10.5220/0001043800870093" @default.
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