Matches in SemOpenAlex for { <https://semopenalex.org/work/W2243973517> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2243973517 endingPage "317" @default.
- W2243973517 startingPage "311" @default.
- W2243973517 abstract "[Objectives]P-glycoprotein(P-gp) plays a crucial role in the bioavailability of many oral drugs,thus limiting their therapeutic potential.We sought to elucidate the effect of lipopolysaccharide(LPS) on the localization and expression of P-gp in liver,kidney,jejunum and ileum in swine.[Methods]The immunohistochemical SABC method combined with DAB staining method was used to localize the P-gp in tissues of swine with C219 as anti-P-gp monoclonal antibody in this study.Imagepro-plus software was used for semi-quantitative analysis of specific staining of P-gp.[Results]The immunohistochemical results showed that P-gp was distributed in the bile canalicular membrane between hepatocytes in liver of the swine.But compared with those of control group,positive staining of P-gp obviously increased after LPS treatment for 3h(P0.05),and then declined to normal level at 6h.In kidney,the main staining was observed in the membrane of proximal tubule and distal tubule in both healthy and LPS treated pigs,and the expression of P-gp significantly increased after LPS treatment for 6h(P0.05).In jejunum and ileum,the special staining of P-gp was visualized mainly on the apical surface of the small intestine villi and glandular epithelium in both health and LPS treated swine.And the intensity was enhanced following LPS treatment for 3h(P0.05) but decreased to normal leval after 6h in the jejunum.No significant difference was found in ileum(P0.05).[Conclusions]The results suggested that the tissues localization of P-gp can not be changed,but the expression level of P-gp could increase following LPS treatment for 3 to 6h,which may have potential role in changing the pharmacokinetics and pharmacodynamic of substrate drugs of P-gp in swine." @default.
- W2243973517 created "2016-06-24" @default.
- W2243973517 creator A5038841946 @default.
- W2243973517 creator A5061631923 @default.
- W2243973517 creator A5067814400 @default.
- W2243973517 creator A5069484567 @default.
- W2243973517 creator A5076286645 @default.
- W2243973517 date "2015-01-01" @default.
- W2243973517 modified "2023-09-27" @default.
- W2243973517 title "Effect of LPS on P-glycoprotein localization and expression in live, kidney and small intestines of swine." @default.
- W2243973517 hasPublicationYear "2015" @default.
- W2243973517 type Work @default.
- W2243973517 sameAs 2243973517 @default.
- W2243973517 citedByCount "0" @default.
- W2243973517 crossrefType "journal-article" @default.
- W2243973517 hasAuthorship W2243973517A5038841946 @default.
- W2243973517 hasAuthorship W2243973517A5061631923 @default.
- W2243973517 hasAuthorship W2243973517A5067814400 @default.
- W2243973517 hasAuthorship W2243973517A5069484567 @default.
- W2243973517 hasAuthorship W2243973517A5076286645 @default.
- W2243973517 hasConcept C126322002 @default.
- W2243973517 hasConcept C133936738 @default.
- W2243973517 hasConcept C134018914 @default.
- W2243973517 hasConcept C142724271 @default.
- W2243973517 hasConcept C159654299 @default.
- W2243973517 hasConcept C203014093 @default.
- W2243973517 hasConcept C204232928 @default.
- W2243973517 hasConcept C2776366702 @default.
- W2243973517 hasConcept C2777226302 @default.
- W2243973517 hasConcept C2777882243 @default.
- W2243973517 hasConcept C2778707650 @default.
- W2243973517 hasConcept C2778754761 @default.
- W2243973517 hasConcept C2780091579 @default.
- W2243973517 hasConcept C501593827 @default.
- W2243973517 hasConcept C529295009 @default.
- W2243973517 hasConcept C542903549 @default.
- W2243973517 hasConcept C55493867 @default.
- W2243973517 hasConcept C71924100 @default.
- W2243973517 hasConcept C74864618 @default.
- W2243973517 hasConcept C86803240 @default.
- W2243973517 hasConceptScore W2243973517C126322002 @default.
- W2243973517 hasConceptScore W2243973517C133936738 @default.
- W2243973517 hasConceptScore W2243973517C134018914 @default.
- W2243973517 hasConceptScore W2243973517C142724271 @default.
- W2243973517 hasConceptScore W2243973517C159654299 @default.
- W2243973517 hasConceptScore W2243973517C203014093 @default.
- W2243973517 hasConceptScore W2243973517C204232928 @default.
- W2243973517 hasConceptScore W2243973517C2776366702 @default.
- W2243973517 hasConceptScore W2243973517C2777226302 @default.
- W2243973517 hasConceptScore W2243973517C2777882243 @default.
- W2243973517 hasConceptScore W2243973517C2778707650 @default.
- W2243973517 hasConceptScore W2243973517C2778754761 @default.
- W2243973517 hasConceptScore W2243973517C2780091579 @default.
- W2243973517 hasConceptScore W2243973517C501593827 @default.
- W2243973517 hasConceptScore W2243973517C529295009 @default.
- W2243973517 hasConceptScore W2243973517C542903549 @default.
- W2243973517 hasConceptScore W2243973517C55493867 @default.
- W2243973517 hasConceptScore W2243973517C71924100 @default.
- W2243973517 hasConceptScore W2243973517C74864618 @default.
- W2243973517 hasConceptScore W2243973517C86803240 @default.
- W2243973517 hasIssue "2" @default.
- W2243973517 hasLocation W22439735171 @default.
- W2243973517 hasOpenAccess W2243973517 @default.
- W2243973517 hasPrimaryLocation W22439735171 @default.
- W2243973517 hasRelatedWork W1915934302 @default.
- W2243973517 hasRelatedWork W2046528911 @default.
- W2243973517 hasRelatedWork W2370556002 @default.
- W2243973517 hasRelatedWork W2398112701 @default.
- W2243973517 hasRelatedWork W2403195563 @default.
- W2243973517 hasRelatedWork W2412564577 @default.
- W2243973517 hasRelatedWork W2438243802 @default.
- W2243973517 hasRelatedWork W2878987484 @default.
- W2243973517 hasRelatedWork W2895969899 @default.
- W2243973517 hasRelatedWork W2988234451 @default.
- W2243973517 hasRelatedWork W3013136597 @default.
- W2243973517 hasRelatedWork W3024898255 @default.
- W2243973517 hasRelatedWork W3029324455 @default.
- W2243973517 hasRelatedWork W3030317066 @default.
- W2243973517 hasRelatedWork W3032000758 @default.
- W2243973517 hasRelatedWork W3032515124 @default.
- W2243973517 hasRelatedWork W3090214336 @default.
- W2243973517 hasRelatedWork W3134923457 @default.
- W2243973517 hasRelatedWork W3160033022 @default.
- W2243973517 hasRelatedWork W55082427 @default.
- W2243973517 hasVolume "38" @default.
- W2243973517 isParatext "false" @default.
- W2243973517 isRetracted "false" @default.
- W2243973517 magId "2243973517" @default.
- W2243973517 workType "article" @default.