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• W2243979127 abstract "Proteases play important roles in human physiology and pathology. The complement ­system is a proteolytic cascade, where serine proteases activate each other by limited proteolysis in a strictly ordered manner. Serine proteases are essential in both the initiation and the amplification of the cascade. Since uncontrolled complement activation contributes to the development of serious disease conditions, inhibition of the complement serine proteases could be an attractive therapeutic approach. In this chapter, we give a brief overview of the major types of natural serine protease inhibitors and their role in controlling the complement cascade. A special emphasis is laid on C1-inhibitor, a natural complement protease inhibitor, which is approved for clinical use in hereditary angioedema (HAE). We also examine the potential of developing artificial complement protease inhibitors. Synthetic small-molecule drugs can be very efficient serine protease inhibitors, but they usually lack sufficient specificity. A promising approach to yield more specific compounds is the alteration of natural protease inhibitors through engineering or directed evolution resulting in new variants with fine-tuned specificity and enhanced affinity." @default.
• W2243979127 created "2016-06-24" @default.
• W2243979127 creator A5028801295 @default.
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• W2243979127 creator A5036198184 @default.
• W2243979127 creator A5051618397 @default.
• W2243979127 creator A5065944362 @default.
• W2243979127 date "2012-08-10" @default.
• W2243979127 modified "2023-10-07" @default.
• W2243979127 title "Inhibition of the Serine Proteases of the Complement System" @default.
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• W2243979127 doi "https://doi.org/10.1007/978-1-4614-4118-2_2" @default.
• W2243979127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23402017" @default.
• W2243979127 hasPublicationYear "2012" @default.
• W2243979127 type Work @default.

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