FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2244015267> ?p ?o ?g. }

• W2244015267 abstract "Back ground Subsequent to spinal cord injury many pathological changes may occur that could lead to inappropriate environment for repair. The Most important of such changes is the death of neurons. Exogenous administration of growth factors that modulate neuronal survival, synaptic plasticity, and neurotransmission has been proposed as a potential therapeutic treatment for SCI. Among these growth factors, GDNF is a peptide with pleiotropic survival and growth-promoting effects on neurons. In addition, GDNF induces the growth of motor and sensory axons and inhibits neuronal apoptosis. Adult stem cells may provide new strategies to treat SCI. Among various types of candidate stem cells, bone marrow stromal cells (BMSC) are promising because they have shown potential to neuronal differentiation and repair in damaged spinal cord. In this study, we aimed to improve results of treatment using combination of BMSC and GDNF features.Methods:Rats were divided randomly into four groups of six. Spinal cord injury was then performed under general anesthesia using the weight dropping method. The BMSCs were injected on 3th day of post-spinal cord injury. Group one included rats receiving normal saline, group two received BMSC, group three received BMSC infected with adenoviruses encoding the beta-galactosidase gene, and group four received BMSC infected with adenoviruses encoding the GDNF gene. A Basso, Beattie and Bresnahan (BBB) score test was performed for a period of four weeks. Two weeks before the end of BBB, biotin dextran amine was injected intracerebrally followed by tissue staining at the end of the fourth week.Results:There was a significant difference in BBB scores between groups one and four (p<0.05). BBB scale improved to 12.8 points group one, while it was 8.6 in the control. There were no significant differences between other groups. There were significant differences in axon counting between group one and other groups (p<0.0001). Also, there were significant differences in axon counting between group four with groups two and three (p<0.0001).Conclusion:Combined use of these methods (GDNF expressing BMSCs) showed better results in comparison with BMSC alone. In this study the two methods were used simultaneously. The time of injection of BMSCs is very important and so we suggest that other injection times be tested.Key words: BMSC, GDNF, Gene Therapy, Spinal cord injury." @default.
• W2244015267 created "2016-06-24" @default.
• W2244015267 creator A5001179717 @default.
• W2244015267 creator A5008150368 @default.
• W2244015267 creator A5052529482 @default.
• W2244015267 creator A5055239723 @default.
• W2244015267 creator A5073894149 @default.
• W2244015267 creator A5090854647 @default.
• W2244015267 date "2014-05-01" @default.
• W2244015267 modified "2023-10-17" @default.
• W2244015267 title "Repair of Spinal Cord Injury (SCI) Using Bone Marrow Stromal Cell Transfected with Adenoviral Vector Expressing Glial derived Neurotropic Factor (GDNF) in a Rat SCI Model" @default.
• W2244015267 hasPublicationYear "2014" @default.
• W2244015267 type Work @default.
• W2244015267 sameAs 2244015267 @default.
• W2244015267 citedByCount "0" @default.
• W2244015267 crossrefType "journal-article" @default.
• W2244015267 hasAuthorship W2244015267A5001179717 @default.
• W2244015267 hasAuthorship W2244015267A5008150368 @default.
• W2244015267 hasAuthorship W2244015267A5052529482 @default.
• W2244015267 hasAuthorship W2244015267A5055239723 @default.
• W2244015267 hasAuthorship W2244015267A5073894149 @default.
• W2244015267 hasAuthorship W2244015267A5090854647 @default.
• W2244015267 hasConcept C104317684 @default.
• W2244015267 hasConcept C126322002 @default.
• W2244015267 hasConcept C142724271 @default.
• W2244015267 hasConcept C160539049 @default.
• W2244015267 hasConcept C16930146 @default.
• W2244015267 hasConcept C169760540 @default.
• W2244015267 hasConcept C170493617 @default.
• W2244015267 hasConcept C185592680 @default.
• W2244015267 hasConcept C185856081 @default.
• W2244015267 hasConcept C2778334475 @default.
• W2244015267 hasConcept C2780007613 @default.
• W2244015267 hasConcept C2780775167 @default.
• W2244015267 hasConcept C32470452 @default.
• W2244015267 hasConcept C40767141 @default.
• W2244015267 hasConcept C502942594 @default.
• W2244015267 hasConcept C54009773 @default.
• W2244015267 hasConcept C54355233 @default.
• W2244015267 hasConcept C55493867 @default.
• W2244015267 hasConcept C71924100 @default.
• W2244015267 hasConcept C81885089 @default.
• W2244015267 hasConcept C86803240 @default.
• W2244015267 hasConceptScore W2244015267C104317684 @default.
• W2244015267 hasConceptScore W2244015267C126322002 @default.
• W2244015267 hasConceptScore W2244015267C142724271 @default.
• W2244015267 hasConceptScore W2244015267C160539049 @default.
• W2244015267 hasConceptScore W2244015267C16930146 @default.
• W2244015267 hasConceptScore W2244015267C169760540 @default.
• W2244015267 hasConceptScore W2244015267C170493617 @default.
• W2244015267 hasConceptScore W2244015267C185592680 @default.
• W2244015267 hasConceptScore W2244015267C185856081 @default.
• W2244015267 hasConceptScore W2244015267C2778334475 @default.
• W2244015267 hasConceptScore W2244015267C2780007613 @default.
• W2244015267 hasConceptScore W2244015267C2780775167 @default.
• W2244015267 hasConceptScore W2244015267C32470452 @default.
• W2244015267 hasConceptScore W2244015267C40767141 @default.
• W2244015267 hasConceptScore W2244015267C502942594 @default.
• W2244015267 hasConceptScore W2244015267C54009773 @default.
• W2244015267 hasConceptScore W2244015267C54355233 @default.
• W2244015267 hasConceptScore W2244015267C55493867 @default.
• W2244015267 hasConceptScore W2244015267C71924100 @default.
• W2244015267 hasConceptScore W2244015267C81885089 @default.
• W2244015267 hasConceptScore W2244015267C86803240 @default.
• W2244015267 hasLocation W22440152671 @default.
• W2244015267 hasOpenAccess W2244015267 @default.
• W2244015267 hasPrimaryLocation W22440152671 @default.
• W2244015267 hasRelatedWork W132538436 @default.
• W2244015267 hasRelatedWork W1963846589 @default.
• W2244015267 hasRelatedWork W2049188968 @default.
• W2244015267 hasRelatedWork W2066067872 @default.
• W2244015267 hasRelatedWork W2089999520 @default.
• W2244015267 hasRelatedWork W2158395619 @default.
• W2244015267 hasRelatedWork W2231413328 @default.
• W2244015267 hasRelatedWork W2358577340 @default.
• W2244015267 hasRelatedWork W2370911933 @default.
• W2244015267 hasRelatedWork W3032690602 @default.
• W2244015267 isParatext "false" @default.
• W2244015267 isRetracted "false" @default.
• W2244015267 magId "2244015267" @default.
• W2244015267 workType "article" @default.