Matches in SemOpenAlex for { <https://semopenalex.org/work/W2244093653> ?p ?o ?g. }
- W2244093653 abstract "A non-ischemic etiology of sudden cardiac death (SCD), mostly due to various cardiomyopathies (CMP), accounts for about 20% of all SCDs. Most of the major studies of risk factors for SCD have focused on coronary artery disease (CAD). The aim of the present study was to clarify the characteristics of non-ischemic SCD in Northern Finland. In this study, consecutive victims of SCD (n=2661) were prospectively collected, and among whom post-mortem examinations were performed between 1998 and 2007. Information about the SCD victims was obtained from a combination of available medical records, postmortem examination reports, medication used at the time of SCD, and standardized questionnaire filled out by the closest family members of the victims of SCD. We also screened the candidate genes from a Finnish family in which fatal arrhythmias was first manifestation of a cardiac disease. The collagen content of the myocardium from histological samples in victims of SCD due to idiopathic myocardial fibrosis (IMF) was also evaluated. CAD was the most common cause of death (2082 victims, 78.2%). The prevalence of nonischemic SCDs was 21.8% of all the SCDs. After sub-grouping the non-ischemic SCDs into various categories, the most common cause of death was CMP related to obesity (23.7%), followed by alcoholic CMP (19.0%), hypertensive CMP (15.5%) and IMF (13.6%). The association of SCD with IMF is notably frequent among victims <40 years old (28.3%). The prevalence of family history of SCD was significantly higher in the victims of ischemic (34.2%) than non-ischemic SCD (13.4%, P<0.001) or controls (17.6%, P<0.001). Lamin A/C gene mutation R541C was found from Finnish SCD family, in which the IMF was predominant pathologic-anatomic finding. Myocardial type I collagen synthesis was increased in victims of SCD due to IMF. In conclusion, the characteristics of non-ischemic SCD in Finland differ from those reported previously. Higher prevalences of CMP-associated SCDs related to obesity, IMF and alcoholic CMP were observed as clinical and/or pathologic bases for non-ischemic SCD. The family history of SCD is not significantly increased in victims of non-ischemic SCD, suggesting a larger role of sporadic occurrence than inherited traits as the cause of non-ischemic SCD. Replacement of cardiac myocytes by fibrosis can be responsible for fatal cardiac arrhythmias in subjects with the lamin A/C gene mutation. The victims of SCD due to IMF have increased myocardial type I collagen synthesis." @default.
- W2244093653 created "2016-06-24" @default.
- W2244093653 creator A5091830003 @default.
- W2244093653 date "2012-01-01" @default.
- W2244093653 modified "2023-09-24" @default.
- W2244093653 title "Characteristics of victims of non-ischemic sudden cardiac death" @default.
- W2244093653 cites W1487741670 @default.
- W2244093653 cites W1494007673 @default.
- W2244093653 cites W1523512004 @default.
- W2244093653 cites W1598667444 @default.
- W2244093653 cites W1819034412 @default.
- W2244093653 cites W1889002087 @default.
- W2244093653 cites W1951533104 @default.
- W2244093653 cites W1964044304 @default.
- W2244093653 cites W1966219016 @default.
- W2244093653 cites W1968326551 @default.
- W2244093653 cites W1973039354 @default.
- W2244093653 cites W1975925766 @default.
- W2244093653 cites W1977174816 @default.
- W2244093653 cites W1978143456 @default.
- W2244093653 cites W1978953141 @default.
- W2244093653 cites W1979924020 @default.
- W2244093653 cites W1980826920 @default.
- W2244093653 cites W1982225809 @default.
- W2244093653 cites W1982710627 @default.
- W2244093653 cites W1984770008 @default.
- W2244093653 cites W1986735443 @default.
- W2244093653 cites W1987045148 @default.
- W2244093653 cites W1989101440 @default.
- W2244093653 cites W1990139289 @default.
- W2244093653 cites W1992290255 @default.
- W2244093653 cites W1992307061 @default.
- W2244093653 cites W1994788779 @default.
- W2244093653 cites W1994930404 @default.
- W2244093653 cites W1995169649 @default.
- W2244093653 cites W1998609175 @default.
- W2244093653 cites W2002595573 @default.
- W2244093653 cites W2002938395 @default.
- W2244093653 cites W2004652696 @default.
- W2244093653 cites W2004866985 @default.
- W2244093653 cites W2005197311 @default.
- W2244093653 cites W2005405981 @default.
- W2244093653 cites W2008840432 @default.
- W2244093653 cites W2012783022 @default.
- W2244093653 cites W2012957301 @default.
- W2244093653 cites W2013759344 @default.
- W2244093653 cites W20142173 @default.
- W2244093653 cites W2015916542 @default.
- W2244093653 cites W2017137690 @default.
- W2244093653 cites W2018392525 @default.
- W2244093653 cites W2019898117 @default.
- W2244093653 cites W2020985206 @default.
- W2244093653 cites W2023632352 @default.
- W2244093653 cites W2024485314 @default.
- W2244093653 cites W2025389038 @default.
- W2244093653 cites W2027941211 @default.
- W2244093653 cites W2029209225 @default.
- W2244093653 cites W2030704801 @default.
- W2244093653 cites W2031179349 @default.
- W2244093653 cites W2032786923 @default.
- W2244093653 cites W2036198235 @default.
- W2244093653 cites W2037012547 @default.
- W2244093653 cites W2039374034 @default.
- W2244093653 cites W2041301472 @default.
- W2244093653 cites W2042293234 @default.
- W2244093653 cites W2042346825 @default.
- W2244093653 cites W2043978141 @default.
- W2244093653 cites W2044120232 @default.
- W2244093653 cites W2045548568 @default.
- W2244093653 cites W2046466520 @default.
- W2244093653 cites W2047970481 @default.
- W2244093653 cites W2048266671 @default.
- W2244093653 cites W2048374248 @default.
- W2244093653 cites W2049455628 @default.
- W2244093653 cites W2049878628 @default.
- W2244093653 cites W2050364768 @default.
- W2244093653 cites W2052675296 @default.
- W2244093653 cites W2052797600 @default.
- W2244093653 cites W2052834432 @default.
- W2244093653 cites W2053772493 @default.
- W2244093653 cites W2055896381 @default.
- W2244093653 cites W2060018075 @default.
- W2244093653 cites W2060674621 @default.
- W2244093653 cites W2060868333 @default.
- W2244093653 cites W2065046538 @default.
- W2244093653 cites W2065547137 @default.
- W2244093653 cites W2067103900 @default.
- W2244093653 cites W2068650532 @default.
- W2244093653 cites W2068698281 @default.
- W2244093653 cites W2070138557 @default.
- W2244093653 cites W2071038558 @default.
- W2244093653 cites W2071693897 @default.
- W2244093653 cites W2072665166 @default.
- W2244093653 cites W2073084279 @default.
- W2244093653 cites W2073122251 @default.
- W2244093653 cites W2074519955 @default.
- W2244093653 cites W2078081589 @default.
- W2244093653 cites W2080021007 @default.
- W2244093653 cites W2080624466 @default.
- W2244093653 cites W2080786426 @default.