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• W2244232103 abstract "For patients with unilateral primary aldosteronism (PAL), unilateral laparoscopic adrenalectomy (ADX) corrects hypokalemia and leads to cure or improvement in hypertension control. While most studies have focused on clinical and biochemical outcomes, to our knowledge there are no data on the effects of ADX on quality of life (QOL). In the current study, QOL was evaluated prospectively using the SF-36 questionnaire before and 3 and 6 months after ADX in 22 patients [14 males, 8 females; mean age 50.0±2.0 SEM (range 27–69) years] with unilateral PAL who underwent ADX at the Endocrine Hypertension Centre, Greenslopes and Princess Alexandra Hospitals from 2007 through 2008. Pre-operatively, the SF36 score for each QOL domain was lower for unilateral PAL patients than reported for the Australian general population, significantly so for physical functioning (P<0.001), role physical (P<0.001), vitality (P<0.001) and general health (P<0.01). Compared with pre-ADX, there were significant increments in mean scores at 3 months for physical functioning (from 77±21 to 84±24, P<0.05), role physical (63±41 to 84±31, P<0.05), vitality (45±20 to 65±16, P<0.001), general health (65±19 to 76±18, P<0.001), role emotional (73±38 to 96±16, P<0.05), social functioning (P<0.05) and mental health (72±13 to 82±11, P<0.001); and at 6 months for physical functioning (83±27, P<0.05), role physical (83±31, P<0.05), vitality (67±14, P<0.001), general health (75±20, P<0.05), role emotional (92±20, P<0.05) and mental health (80±16, P<0.05). At both 3 and 6 months the scores in each of the eight domains rose to reach those of the normal population. Mean SBP and DBP improved significantly (P<0.001), with 86% of these patients cured of hypertension (BP≥140/90, no drugs) and the remaining 14 % improved. Mean plasma potassium (P<0.001) and renin concentration (P<0.01) rose, whereas mean upright plasma aldosterone, aldosterone/renin ratio and number of antihypertensive agents fell (P<0.001). In conclusion, (1) QOL is impaired in patients with unilateral PAL, and (2) ADX has positive impacts not only on clinical and biochemical parameters but also on QOL, with significant QOL improvement observed as early as 3 months post-ADX and persisting at 6 months." @default.
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• W2244232103 date "2010-01-01" @default.
• W2244232103 modified "2023-09-27" @default.
• W2244232103 title "Improved quality of life following unilateral laparoscopic adrenalectomy in patients with unilateral primary aldosteronism" @default.
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