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- W2244299717 endingPage "395" @default.
- W2244299717 startingPage "385" @default.
- W2244299717 abstract "Developments in chromosome conformation capture (3C) technologies have revealed that the three-dimensional organization of a genome leads widely separated functional elements to reside in close proximity. However, the mechanisms responsible for mediating long-range interactions are still not completely known. In this review, we firstly evaluate and compare the current seven 3C-based methods, summarize their advantages and discuss their limitations to our current understanding of genome structure. Then, software packages available to perform the analysis of 3C-based data are described. Moreover, we review the insights into the two main mechanisms of long-range interactions, which regulate gene expression by bringing together promoters and distal regulatory elements and by creating structural domains that contain functionally related genes with similar expression landscape. At last, we summarize what is known about the mediating factors involved in stimulation/repression of long-range interactions, such as transcription factors and noncoding RNAs." @default.
- W2244299717 created "2016-06-24" @default.
- W2244299717 creator A5029632441 @default.
- W2244299717 creator A5044674429 @default.
- W2244299717 creator A5049807407 @default.
- W2244299717 creator A5054213249 @default.
- W2244299717 creator A5059553859 @default.
- W2244299717 creator A5067221645 @default.
- W2244299717 creator A5071785481 @default.
- W2244299717 date "2016-01-14" @default.
- W2244299717 modified "2023-09-25" @default.
- W2244299717 title "Exploring the mechanisms of genome-wide long-range interactions: interpreting chromosome organization" @default.
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- W2244299717 doi "https://doi.org/10.1093/bfgp/elv062" @default.