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• W2244366989 abstract "The thalamus acts as a conduit for sensory and other information traveling to the cortex. In response to continuous sensory stimulation in vivo, the firing rate of thalamocortical neurons initially increases, but then within a minute firing rate decreases and T-type Ca(2+) channel-dependent action potential burst firing emerges. While neuromodulatory systems could play a role in this inhibitory response, we instead report a novel and cell-autonomous inhibitory mechanism intrinsic to the thalamic relay neuron. Direct intracellular stimulation of thalamocortical neuron firing initially triggered a continuous and high rate of action potential discharge, but within a minute membrane potential (Vm) was hyperpolarized and firing rate to the same stimulus was decreased. This self-inhibition was observed across a wide variety of thalamic nuclei, and in a subset firing mode switched from tonic to bursting. The self-inhibition resisted blockers of intracellular Ca(2+) signaling, Na(+)-K(+)-ATPases, and G protein-regulated inward rectifier (GIRK) channels as implicated in other neuron subtypes, but instead was in part inhibited by an ATP-sensitive K(+) channel blocker. The results identify a new homeostatic mechanism within the thalamus capable of gating excitatory signals at the single-cell level." @default.
• W2244366989 created "2016-06-24" @default.
• W2244366989 creator A5000807678 @default.
• W2244366989 creator A5024049848 @default.
• W2244366989 date "2015-07-01" @default.
• W2244366989 modified "2023-10-17" @default.
• W2244366989 title "Self-regulation of adult thalamocortical neurons" @default.
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• W2244366989 doi "https://doi.org/10.1152/jn.00800.2014" @default.
• W2244366989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4507976" @default.
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• W2244366989 hasPublicationYear "2015" @default.
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