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- W2244486394 abstract "The role of histidine on DNA breakage induced by hydrogen peroxide (H2O2) and ferric ions or by H2O2 and cupric ions was studied on purified DNA. L-histidine slightly reduced DNA breakage by H2O2 and Fe3+ but greatly inhibited DNA breakage by H2O2 and Cu2+. However, only when histidine was present, the addition of EDTA to H2O2 and Fe3+ exhibited a bimodal dose response curve depending on the chelator metal ratio. The enhancing effect of histidine on the rate of DNA degradation by H2O2 was maximal at a chelator metal ratio between 0.2 and 0.5, and was specific for iron. When D-histidine replaced L-histidine, the same pattern of EDTA dose response curve was observed. Superoxide dismutase greatly inhibited the rate of DNA degradation induced by H2O2, Fe3+, EDTA and L-histidine involving the superoxide radical.These studies suggest that the enhancing effect of histidine on the rate of DNA degradation by H2O2 and Fe3+ is mediated by an oxidant which could be a ferrous-dioxygen-ferric chelate complex or a chelate-ferryl ion." @default.
- W2244486394 created "2016-06-24" @default.
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- W2244486394 date "1990-01-01" @default.
- W2244486394 modified "2023-09-26" @default.
- W2244486394 title "DNA Single Strand Breakage by H<sub>2</sub>O<sub>2</sub>and Ferric or Cupric Ions: Its Modulation by Histidine" @default.
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- W2244486394 doi "https://doi.org/10.3109/10715769009148571" @default.
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