Matches in SemOpenAlex for { <https://semopenalex.org/work/W2244574929> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2244574929 abstract "Background. An “In Silico 2D/3D Conformer Screening” for structural similar antitumor substances to Curcumin was carried out and the novel antrachinone BTB14431 was found. Emodin, contained in several Chinese medical plants and BTB14431 are known to be potential inhibitors of the COP9-signalosome - stabilizing the tumor suppressor protein p53. The aim of this study was to analyze the suppressing effects on colorectal cancer in a standardized rat model (WAG/Rij). Methods. A suspension of CC531 colon cancer cells was applied to the cecum after laparotomy and, additionally, at the back of animals. Therapy was conducted twice daily for 7 days, with increasing doses of BTB14431, Emodin and with isotone sodium chloride solution (control) intravenously (iv) or intraperitoneally (ip). Therapy was initiated the day of tumor cell application. Peripheral blood samples were taken before surgery and on day 7. 21 days after the end of therapy, the animals were euthanized and tumor growth was evaluated. Results. Data showed a downward trend of the total tumor growth after iv and ip treatment with low doses of BTB14431 and Emodin. Differential blood analysis showed apoptosis, but no major changes in hemogram. Increasing doses of Emodin elevated total mortality rate exponentially. Conclusions. Although apoptosis was verified, no significant tumor suppressing effects could be observed for iv and ip treatment of both agents in our model. This stays in contrast to former in vitro studies. Agents remain viable novel substances. They will be the subject of upcoming studies. Additional data is needed to evaluate the significance of the “In Silico Screening” to identify potential in vivo anti-tumor drugs." @default.
- W2244574929 created "2016-06-24" @default.
- W2244574929 creator A5001976020 @default.
- W2244574929 creator A5012847065 @default.
- W2244574929 creator A5020319990 @default.
- W2244574929 creator A5025625889 @default.
- W2244574929 creator A5031732724 @default.
- W2244574929 creator A5033225020 @default.
- W2244574929 creator A5053868274 @default.
- W2244574929 creator A5070739403 @default.
- W2244574929 creator A5071540168 @default.
- W2244574929 date "2014-03-26" @default.
- W2244574929 modified "2023-09-30" @default.
- W2244574929 title "Dose dependent role of Emodin and BTB14431 in suspension colon cancer model in rats" @default.
- W2244574929 cites W1544572671 @default.
- W2244574929 cites W175416543 @default.
- W2244574929 cites W1973867263 @default.
- W2244574929 cites W1975253820 @default.
- W2244574929 cites W1992135429 @default.
- W2244574929 cites W1996481818 @default.
- W2244574929 cites W2017365542 @default.
- W2244574929 cites W2018382375 @default.
- W2244574929 cites W2035187030 @default.
- W2244574929 cites W2037441385 @default.
- W2244574929 cites W2041220716 @default.
- W2244574929 cites W2048458354 @default.
- W2244574929 cites W2069506489 @default.
- W2244574929 cites W2079347472 @default.
- W2244574929 cites W2092702226 @default.
- W2244574929 cites W2094640169 @default.
- W2244574929 cites W2096743657 @default.
- W2244574929 cites W2107386750 @default.
- W2244574929 cites W2129514149 @default.
- W2244574929 cites W2150429087 @default.
- W2244574929 cites W2415122671 @default.
- W2244574929 cites W3160726523 @default.
- W2244574929 cites W1984878981 @default.
- W2244574929 doi "https://doi.org/10.7287/peerj.preprints.304v1" @default.
- W2244574929 hasPublicationYear "2014" @default.
- W2244574929 type Work @default.
- W2244574929 sameAs 2244574929 @default.
- W2244574929 citedByCount "0" @default.
- W2244574929 crossrefType "posted-content" @default.
- W2244574929 hasAuthorship W2244574929A5001976020 @default.
- W2244574929 hasAuthorship W2244574929A5012847065 @default.
- W2244574929 hasAuthorship W2244574929A5020319990 @default.
- W2244574929 hasAuthorship W2244574929A5025625889 @default.
- W2244574929 hasAuthorship W2244574929A5031732724 @default.
- W2244574929 hasAuthorship W2244574929A5033225020 @default.
- W2244574929 hasAuthorship W2244574929A5053868274 @default.
- W2244574929 hasAuthorship W2244574929A5070739403 @default.
- W2244574929 hasAuthorship W2244574929A5071540168 @default.
- W2244574929 hasBestOaLocation W22445749291 @default.
- W2244574929 hasConcept C104317684 @default.
- W2244574929 hasConcept C121608353 @default.
- W2244574929 hasConcept C126322002 @default.
- W2244574929 hasConcept C143998085 @default.
- W2244574929 hasConcept C185592680 @default.
- W2244574929 hasConcept C190283241 @default.
- W2244574929 hasConcept C202751555 @default.
- W2244574929 hasConcept C2775905019 @default.
- W2244574929 hasConcept C2777507495 @default.
- W2244574929 hasConcept C2778248515 @default.
- W2244574929 hasConcept C502942594 @default.
- W2244574929 hasConcept C526805850 @default.
- W2244574929 hasConcept C55493867 @default.
- W2244574929 hasConcept C71924100 @default.
- W2244574929 hasConcept C98274493 @default.
- W2244574929 hasConceptScore W2244574929C104317684 @default.
- W2244574929 hasConceptScore W2244574929C121608353 @default.
- W2244574929 hasConceptScore W2244574929C126322002 @default.
- W2244574929 hasConceptScore W2244574929C143998085 @default.
- W2244574929 hasConceptScore W2244574929C185592680 @default.
- W2244574929 hasConceptScore W2244574929C190283241 @default.
- W2244574929 hasConceptScore W2244574929C202751555 @default.
- W2244574929 hasConceptScore W2244574929C2775905019 @default.
- W2244574929 hasConceptScore W2244574929C2777507495 @default.
- W2244574929 hasConceptScore W2244574929C2778248515 @default.
- W2244574929 hasConceptScore W2244574929C502942594 @default.
- W2244574929 hasConceptScore W2244574929C526805850 @default.
- W2244574929 hasConceptScore W2244574929C55493867 @default.
- W2244574929 hasConceptScore W2244574929C71924100 @default.
- W2244574929 hasConceptScore W2244574929C98274493 @default.
- W2244574929 hasLocation W22445749291 @default.
- W2244574929 hasOpenAccess W2244574929 @default.
- W2244574929 hasPrimaryLocation W22445749291 @default.
- W2244574929 hasRelatedWork W1975253820 @default.
- W2244574929 hasRelatedWork W2013486554 @default.
- W2244574929 hasRelatedWork W2041978487 @default.
- W2244574929 hasRelatedWork W2064328049 @default.
- W2244574929 hasRelatedWork W2355227395 @default.
- W2244574929 hasRelatedWork W2365479582 @default.
- W2244574929 hasRelatedWork W2380680628 @default.
- W2244574929 hasRelatedWork W2962756305 @default.
- W2244574929 hasRelatedWork W3004259476 @default.
- W2244574929 hasRelatedWork W4309211534 @default.
- W2244574929 isParatext "false" @default.
- W2244574929 isRetracted "false" @default.
- W2244574929 magId "2244574929" @default.
- W2244574929 workType "article" @default.