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• W2244844384 abstract "The vitrification and thawing of mature human eggs are among the newest of assisted reproductive technologies (ART), and present the opportunity for creating donor egg banks. Given some of the advantages to the recipient patient of using vitrified eggs (VE), e.g., greater selection of donors, lower cost, and more convenience with no need for cycle synchronization with the donor, ART laboratories may encounter VE cycles more frequently, requiring development of expertise in using VE. To learn how VE compare with fresh eggs (FE) and identify the technical differences in using each egg type, we compared clinical outcomes for recipients of VE and FE from July 1, 2012 through December 31, 2014. VE were purchased from a single egg bank in this study. Retrospective data analysis of IVF cycles of recipients of FE or VE from a single VE bank. Statistical analyses were conducted by Student's t-test and Mann-Whitney U test. Recipient cycles of FE or VE were compared for average number of eggs per cycle, fertilization rate, #embryo transfers, average # embryos transferred, pregnancy rate,and chance for the recipient to have supernumerary embryos for cryopreservation. FE were inseminated conventionally or by ICSI; VE received ICSI exclusively. Assisted hatching was used electively on cleavage stage embryos (CSE)from FE but on all VE CSE. Embryologists were trained in the specific thawing protocol of VE obtained from a single egg bank. 80 FE and 168 VE cycles were analyzed, with 1595 and 1171 eggs, respectively, available for the recipients (averages of 19.9 FE vs 7 VE per recipient). Fertilization rates of 76.±18.5% and 84.±18.0%)of inseminated FE and VE, respectively, were achieved(significant, p=0.0011) leading to averages of 1.2 (FE) and 1.3 (VE) embryos per transfer (no statistical difference)and 49/75 FE and 91/158 VE clinical pregnancies per ET (not significant, chi-squared=1.2699, p=0260).72.5% of FE recipients had frozen embryos after ET compared to 51.2% of VE. Despite the almost 3-fold higher number of eggs available per treatment cycle for FE vs. VE, comparable fertilization rates, application of elective single embryo transfer, and clinical pregnancy rates per ET were obtained. FE patients had an advantage in more frequently having supernumerary embryos for freezing from their cycles. VE can provide more cost-effective and convenient treatment to patients but require specific training in the thawing protocol prescribed by the egg bank to realize this advantage." @default.
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• W2244844384 date "2015-09-01" @default.
• W2244844384 modified "2023-09-27" @default.
• W2244844384 title "Donor eggs: on ice, still nice?" @default.
• W2244844384 doi "https://doi.org/10.1016/j.fertnstert.2015.07.1118" @default.
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