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• W2244851570 abstract "Abstract How new mutations contribute to genetic variation is a key question in biology. Although the evolutionary fate of an allele is largely determined by its heterozygous effect, most estimates of mutational variance and mutational effects derive from highly inbred lines, where new mutations are present in homozygous form. In an attempt to overcome this limitation, middle-class neighborhood (MCN) experiments have been used to assess the fitness effect of new mutations in heterozygous form. However, because MCN populations harbor substantial standing genetic variance, estimates of mutational variance have not typically been available from such experiments. Here we employ a modification of the animal model to analyze data from 22 generations of Drosophila serrata bred in an MCN design. Mutational heritability, measured for eight cuticular hydrocarbons, 10 wing-shape traits, and wing size in this outbred genetic background, ranged from 0.0006 to 0.006 (with one exception), a similar range to that reported from studies employing inbred lines. Simultaneously partitioning the additive and mutational variance in the same outbred population allowed us to quantitatively test the ability of mutation-selection balance models to explain the observed levels of additive and mutational genetic variance. The Gaussian allelic approximation and house-of-cards models, which assume real stabilizing selection on single traits, both overestimated the genetic variance maintained at equilibrium, but the house-of-cards model was a closer fit to the data. This analytical approach has the potential to be broadly applied, expanding our understanding of the dynamics of genetic variance in natural populations." @default.
• W2244851570 created "2016-06-24" @default.
• W2244851570 creator A5006739200 @default.
• W2244851570 creator A5017400602 @default.
• W2244851570 creator A5035695817 @default.
• W2244851570 date "2015-09-16" @default.
• W2244851570 modified "2023-10-17" @default.
• W2244851570 title "Simultaneous Estimation of Additive and Mutational Genetic Variance in an Outbred Population of <i>Drosophila serrata</i>" @default.
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• W2244851570 doi "https://doi.org/10.1534/genetics.115.178632" @default.
• W2244851570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4649648" @default.
• W2244851570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26384357" @default.
• W2244851570 hasPublicationYear "2015" @default.
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