Matches in SemOpenAlex for { <https://semopenalex.org/work/W2245038329> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2245038329 abstract "Background: Recently, cigarette smoking has been associated with the development of several auto-immune diseases, including rheumatoid arthritis and inflammatory bowel disease (IBD). The cellular and molecular mechanisms through which cigarette smoking predisposes to IBD are unknown. Cigarette smoke-induced apoptosis is described in several in vivo and in vitro experiments, and might play a role in the pathogenesis of several smoke-associated diseases. The aim of this study was to quantify apoptosis in normal murine Follicle-Associated Epithelium (FAE) and compare this to apoptosis in FAE of smoking mice.Methods: 8 C57BL/6 male mice were exposed to cigarette smoke for 24 weeks (chronic exposure); a control group of 8 mice was exposed to air during the same period. After 24 weeks the mice were sacrificed and Peyer’s patches of each mouse were dissected for histology. Immunohistochemistry for caspase-3 was performed on paraffin-embedded tissue sections of 11 Peyer’s patches of smoking animals and 11 Peyer’s patches of controls. To compare apoptotic activities between smokers and controls, the apoptotic index (percentage of apoptotic cells per 100 cells) in the FAE was calculated. An unpaired student T-test was applied.Results: A statistically significant increase in apoptosis of FAE cells was observed in smoking mice compared to air-exposed mice (P=0.002). In the FAE of smoking animals, the mean apoptotic index was 1.82 with a range of 1.11 to 3.00, whereas the mean apoptotic index in non-smoking animals was 0.92 (range 0.24 -2.06). Most apoptotic cells in both groups were seen at the apex of the FAE. Conclusion: We quantified rates of apoptosis in the FAE of murine Peyer’s patches. Furthermore we compared apoptosis in the FAE of smoking mice versus non-smoking siblings and observed an increased apoptotic index in the FAE of smoking animals. Our results demonstrate that cigarette smoke induces a significant increase of apoptosis in the FAE of murine Peyer’s patches and may point to a role for smoking in the pathogenesis of intestinal inflammation. Further investigation needs to clarify whether this increase in apoptosis influences normal function of the FAE." @default.
- W2245038329 created "2016-06-24" @default.
- W2245038329 creator A5005310938 @default.
- W2245038329 creator A5011035454 @default.
- W2245038329 creator A5014350243 @default.
- W2245038329 creator A5018782895 @default.
- W2245038329 creator A5035081644 @default.
- W2245038329 creator A5056267394 @default.
- W2245038329 creator A5080789914 @default.
- W2245038329 date "2009-01-01" @default.
- W2245038329 modified "2023-09-23" @default.
- W2245038329 title "Cigarette smoke induces apoptosis in the follicle-associated epithelium of murine Peyer's patches" @default.
- W2245038329 hasPublicationYear "2009" @default.
- W2245038329 type Work @default.
- W2245038329 sameAs 2245038329 @default.
- W2245038329 citedByCount "0" @default.
- W2245038329 crossrefType "journal-article" @default.
- W2245038329 hasAuthorship W2245038329A5005310938 @default.
- W2245038329 hasAuthorship W2245038329A5011035454 @default.
- W2245038329 hasAuthorship W2245038329A5014350243 @default.
- W2245038329 hasAuthorship W2245038329A5018782895 @default.
- W2245038329 hasAuthorship W2245038329A5035081644 @default.
- W2245038329 hasAuthorship W2245038329A5056267394 @default.
- W2245038329 hasAuthorship W2245038329A5080789914 @default.
- W2245038329 hasConcept C126322002 @default.
- W2245038329 hasConcept C142724271 @default.
- W2245038329 hasConcept C150903083 @default.
- W2245038329 hasConcept C190283241 @default.
- W2245038329 hasConcept C203014093 @default.
- W2245038329 hasConcept C207001950 @default.
- W2245038329 hasConcept C2777575956 @default.
- W2245038329 hasConcept C2780942790 @default.
- W2245038329 hasConcept C55493867 @default.
- W2245038329 hasConcept C71924100 @default.
- W2245038329 hasConcept C86803240 @default.
- W2245038329 hasConcept C8891405 @default.
- W2245038329 hasConceptScore W2245038329C126322002 @default.
- W2245038329 hasConceptScore W2245038329C142724271 @default.
- W2245038329 hasConceptScore W2245038329C150903083 @default.
- W2245038329 hasConceptScore W2245038329C190283241 @default.
- W2245038329 hasConceptScore W2245038329C203014093 @default.
- W2245038329 hasConceptScore W2245038329C207001950 @default.
- W2245038329 hasConceptScore W2245038329C2777575956 @default.
- W2245038329 hasConceptScore W2245038329C2780942790 @default.
- W2245038329 hasConceptScore W2245038329C55493867 @default.
- W2245038329 hasConceptScore W2245038329C71924100 @default.
- W2245038329 hasConceptScore W2245038329C86803240 @default.
- W2245038329 hasConceptScore W2245038329C8891405 @default.
- W2245038329 hasIssue "1" @default.
- W2245038329 hasLocation W22450383291 @default.
- W2245038329 hasOpenAccess W2245038329 @default.
- W2245038329 hasPrimaryLocation W22450383291 @default.
- W2245038329 hasRelatedWork W2012079864 @default.
- W2245038329 hasRelatedWork W2043813605 @default.
- W2245038329 hasRelatedWork W2075639659 @default.
- W2245038329 hasRelatedWork W2147052767 @default.
- W2245038329 hasRelatedWork W225889781 @default.
- W2245038329 hasRelatedWork W2323872743 @default.
- W2245038329 hasRelatedWork W2384977353 @default.
- W2245038329 hasRelatedWork W2394691710 @default.
- W2245038329 hasRelatedWork W2421755315 @default.
- W2245038329 hasRelatedWork W2425407049 @default.
- W2245038329 hasRelatedWork W2428247593 @default.
- W2245038329 hasRelatedWork W2461280300 @default.
- W2245038329 hasRelatedWork W2729380462 @default.
- W2245038329 hasRelatedWork W2896681321 @default.
- W2245038329 hasRelatedWork W2972281243 @default.
- W2245038329 hasRelatedWork W2982445149 @default.
- W2245038329 hasRelatedWork W3025101492 @default.
- W2245038329 hasRelatedWork W3141858375 @default.
- W2245038329 hasRelatedWork W2416167780 @default.
- W2245038329 hasRelatedWork W3205724167 @default.
- W2245038329 hasVolume "72" @default.
- W2245038329 isParatext "false" @default.
- W2245038329 isRetracted "false" @default.
- W2245038329 magId "2245038329" @default.
- W2245038329 workType "article" @default.