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- W2245140026 abstract ": Background: Growing evidence indicates that pre-inflammatory cytokines and cellular adhesionmolecules that increase vascular endothelial activity are more sensitive in anticipatingcardiovascular diseases. These novel inflammatory markers may play an important role inpathogenesis of atherosclerosis. The purpose of this study was to determine the changes in preinflammatorycytokines and markers of vascular inflammation after regular endurance training inWistar rats.Materials and Methods: In this experimental study, 24 male rats (3 months old) were kept in acontrolled condition and were divided into two different control (n=12, weight=211±3gr) andexperimental (n=12, weight=208±7gr) groups. The training program was performed 3 times aweek for 12 weeks under certain duration and speed. The blood sampling was performed after 14fasting hours in different stages and with the same conditions. Elisa trade kits were used to measuresICAM-1, TNF-a, and IL-1β. Resulting data were analyzed by dependent and independent t-tests(α=0.05).Results: A significant increase was observed in IL-1β (p=0.045), TNF-a (p=0.047), and sICAM-1(p=0.028) levels in control group, while a significant decrease in IL-1β (p=0.002), TNF-a(p=0.016), and sICAM-1 levels was shown in experimental group (p=0.000). Also, a significantdifference was observed in comparison between control and experimental groups about IL-1β(p=0.039), TNF-a (p=0.028), and sICAM-1 (p=0.000).Conclusion: The results of this study showed that regular endurance training (Vo2max 55-85%)reduces the amounts of inflammatory markers of cardiovascular diseases including sICAM-1, TNFa,and IL-1β. This training method can play an efficient role in declining the risk of atherosclerosisby lowering markers of vascular inflammation." @default.
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- W2245140026 date "2008-07-01" @default.
- W2245140026 modified "2023-09-24" @default.
- W2245140026 title "Changes in Pre-Inflammatory Cytokines and Markers of Vascular Inflammation after Regular Endurance Training" @default.
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