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- W2245286367 abstract "Background The incidence of oesophageal adenocarcinoma (OA) isincreasing rapidly with nearly all OA arising from underlying Barrett’soesophagus (BO). The primary risk factors for BO are gastro-oesophagealrefl ux (GOR) and obesity. The risk of obesity remains after controlling forGOR, suggesting that non-refl ux obesity factors may be important. Themetabolic syndrome (MS) results from obesity related hormonal and systemicinfl ammatory changes and is associated with breast, prostate andcolon cancers. The association between MS and BO is unknown.Aim To conduct a case-control study to quantify the association betweenMS and BO.Methods We undertook a structured interview, clinical and anthropometricmeasures and fasting metabolic and hormonal studies within acase-control study conducted in Brisbane, Australia. We recruited 236cases with histologically confi rmed BO diagnosed 2003–6 and 237 controlsfrom the electoral roll, frequency matched by age and sex to cases.Odds ratios (OR) and 95% confi dence intervals (CI) were estimated usingmultivariable logistic regression analysis.Results The prevalence of MS was 63% in cases and 47% in controls (p= 0.0005). There was a signifi cantly increased risk of BO among thosewith MS (OR 1.91 95%CI 1.32–2.76). The risk was unaffected in a logisticregression model adjusting for age, sex, and use of aspirin, NSAIDs,alcohol and cigarettes (OR 1.91 95%CI 1.27–2.88). Further adjustment forBMI (OR 1.62 95%CI 1.03–2.54) and GOR (1.34 95%CI 0.80–2.23)modestly attenuated the association.Conclusions MS is associated with an increased risk of BO. This associationis not explained simply by higher BMI or GOR among cases. Themechanism of this association remains unknown but hormonal and systemicinfl ammatory changes associated with obesity are factors warrantingfurther study." @default.
- W2245286367 created "2016-06-24" @default.
- W2245286367 date "2010-10-01" @default.
- W2245286367 modified "2023-09-25" @default.
- W2245286367 title "Gastrointestinal Cancer" @default.
- W2245286367 doi "https://doi.org/10.1111/j.1440-1746.2010.06453.x" @default.
- W2245286367 hasPublicationYear "2010" @default.
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