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- W2245303435 abstract "Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV) patients using tetramer-associated magnetic enrichment to study antigen-specific inexperienced CD8(+) T cells (i.e., tumor or unrelated virus-specific populations in tumor-free and sero-negative individuals). cHCV showed normal precursor frequencies, but increased proportions of memory-phenotype inexperienced cells, as compared to healthy donors or cured HCV patients. These observations could be explained by low surface expression of CD5, a negative regulator of TCR signaling. Accordingly, we demonstrated TCR hyperactivation and generation of potent CD8(+) T cell responses from the altered T cell repertoire of cHCV patients. In sum, we provide the first evidence that naïve CD8(+) T cells are dysregulated during cHCV infection, and establish a new mechanism of immune perturbation secondary to chronic infection." @default.
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- W2245303435 date "2015-11-14" @default.
- W2245303435 modified "2023-10-09" @default.
- W2245303435 title "Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients" @default.
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- W2245303435 doi "https://doi.org/10.7554/elife.07916" @default.
- W2245303435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4752008" @default.
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