Matches in SemOpenAlex for { <https://semopenalex.org/work/W2245423193> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2245423193 endingPage "10036" @default.
- W2245423193 startingPage "10036" @default.
- W2245423193 abstract "10036 Background: Cholangiocarcinomas (CCC) are the second most common primary hepatic malignancy with a still poor prognosis and arise from biliary epithelia or cholangiocytes. Until now, less is known about the molecular pathways leeding to CCC. Methods: Oligonucleotide arrays were used to analyze gene expression profiles of 8 intrahepatic CCCs. After isolation of tRNA and transcription into cDNA, biotin-labelled cRNA probes were hybridized to GeneArrays (Affymetrix U 133A) containing probes of more than 22.000 genes/ESTs. For two-dimensional cluster analysis we used special software programs (Genexplore, GeneSpring). Dysregulated genes were determined by presence in more than 70% and a 2-fold change in relation to the corresponding non-malignant liver tissue. Lightcycler analysis were performed to validate the expression datas of dysregulated genes. Results: A total of 694 dysregulated genes (330 up-/364 down-regulated, compared with corresponding non-malignant tissue) were detected. As the gene with the highest and most consistent upregulation we were able to identify osteopontin (OPN) with an average 5-fold overexpression in all CCC tissues. OPN is an acidic phosphoprotein that is secreted by osteoblasts, macrophages and many other cell types and binds to a variety of cell surface receptors (integrins/CD44). OPN is multifunctional, with activities in cell migration, regulation of bone metabolism, immune cell function and control of tumor cell phenotype. Elevated OPN levels were seen in different tumors but until now no data exist about the expression in CCCs. As one possible interaction in human carcinogenesis, OPN has recently been shown to be a novel substrate for some MMPs, which play an importand role in tumor invasion and metastasis. Conclusions: This is the first report about an overexpression of OPN in CCC and our data indicate an important role in cholangiocarcinogenesis. Further studies are needed to illucidate the moleculargenetic mechanisms of OPN interactions in CCC. No significant financial relationships to disclose." @default.
- W2245423193 created "2016-06-24" @default.
- W2245423193 creator A5003863265 @default.
- W2245423193 creator A5021475934 @default.
- W2245423193 creator A5044072443 @default.
- W2245423193 creator A5063926894 @default.
- W2245423193 creator A5064129630 @default.
- W2245423193 creator A5079574806 @default.
- W2245423193 date "2006-06-20" @default.
- W2245423193 modified "2023-09-27" @default.
- W2245423193 title "The gene coding for secreted phosphoprotein1/osteopontin is the most overexpressed gene in cholangiocarcinoma—detected by oligonucleotide arrays and LightCycler analysis" @default.
- W2245423193 doi "https://doi.org/10.1200/jco.2006.24.18_suppl.10036" @default.
- W2245423193 hasPublicationYear "2006" @default.
- W2245423193 type Work @default.
- W2245423193 sameAs 2245423193 @default.
- W2245423193 citedByCount "0" @default.
- W2245423193 crossrefType "journal-article" @default.
- W2245423193 hasAuthorship W2245423193A5003863265 @default.
- W2245423193 hasAuthorship W2245423193A5021475934 @default.
- W2245423193 hasAuthorship W2245423193A5044072443 @default.
- W2245423193 hasAuthorship W2245423193A5063926894 @default.
- W2245423193 hasAuthorship W2245423193A5064129630 @default.
- W2245423193 hasAuthorship W2245423193A5079574806 @default.
- W2245423193 hasConcept C104317684 @default.
- W2245423193 hasConcept C1491633281 @default.
- W2245423193 hasConcept C150194340 @default.
- W2245423193 hasConcept C153911025 @default.
- W2245423193 hasConcept C203014093 @default.
- W2245423193 hasConcept C2779018089 @default.
- W2245423193 hasConcept C2780804394 @default.
- W2245423193 hasConcept C2780932548 @default.
- W2245423193 hasConcept C502942594 @default.
- W2245423193 hasConcept C54355233 @default.
- W2245423193 hasConcept C555283112 @default.
- W2245423193 hasConcept C86803240 @default.
- W2245423193 hasConceptScore W2245423193C104317684 @default.
- W2245423193 hasConceptScore W2245423193C1491633281 @default.
- W2245423193 hasConceptScore W2245423193C150194340 @default.
- W2245423193 hasConceptScore W2245423193C153911025 @default.
- W2245423193 hasConceptScore W2245423193C203014093 @default.
- W2245423193 hasConceptScore W2245423193C2779018089 @default.
- W2245423193 hasConceptScore W2245423193C2780804394 @default.
- W2245423193 hasConceptScore W2245423193C2780932548 @default.
- W2245423193 hasConceptScore W2245423193C502942594 @default.
- W2245423193 hasConceptScore W2245423193C54355233 @default.
- W2245423193 hasConceptScore W2245423193C555283112 @default.
- W2245423193 hasConceptScore W2245423193C86803240 @default.
- W2245423193 hasIssue "18_suppl" @default.
- W2245423193 hasLocation W22454231931 @default.
- W2245423193 hasOpenAccess W2245423193 @default.
- W2245423193 hasPrimaryLocation W22454231931 @default.
- W2245423193 hasRelatedWork W1952035774 @default.
- W2245423193 hasRelatedWork W2009966535 @default.
- W2245423193 hasRelatedWork W2097331814 @default.
- W2245423193 hasRelatedWork W2109413567 @default.
- W2245423193 hasRelatedWork W2150820520 @default.
- W2245423193 hasRelatedWork W2393243402 @default.
- W2245423193 hasRelatedWork W3118609733 @default.
- W2245423193 hasRelatedWork W3165465243 @default.
- W2245423193 hasRelatedWork W3193292905 @default.
- W2245423193 hasRelatedWork W3209384962 @default.
- W2245423193 hasVolume "24" @default.
- W2245423193 isParatext "false" @default.
- W2245423193 isRetracted "false" @default.
- W2245423193 magId "2245423193" @default.
- W2245423193 workType "article" @default.