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- W224554924 abstract "The effects of growth phase and chemicals on PLD repair were studied in X-irradiated Chinese hamster hai cells. The change in capacity of cells in different growth phases to repair PLD was investigated. Starting from cells in the log phase, the magnitude of PLD repair during 10 hr of postirradiation incubation in Hanks' balanced salt solution increased from 2.5 to 18 as the cultures approached the stationary phase, which occurred on the 7th or 8th day. The effects of chemicals dissolved in Hanks' BSS on PLD repair were studied using 10th- or 12th-day cultures. Among the chemicals tested, caffeine and cordycepin were effective in inhibiting PLD repair, the latter being more potent. However, the time course of cordycepin's action showed a fall in the surviving fraction followed by a rise, suggesting degradation of the drug. When 2′-deoxycoformycin, an inhibitor of adenosine deaminase, was combined with cordycepin, the effect of cordycepin was enhanced. Due to this prevention of the deamination of cordycepin..." @default.
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- W224554924 date "1980-11-01" @default.
- W224554924 modified "2023-10-03" @default.
- W224554924 title "Inhibition of X-Ray-Induced Potentially Lethal Damage (PLD) Repair by Cordycepin (3′-Deoxyadenosine) and Enhancement of Its Action by 2′-Deoxycoformycin in Chinese Hamster hai Cells in the Stationary Phase in Vitro" @default.
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- W224554924 doi "https://doi.org/10.2307/3575298" @default.
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