FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W224584583> ?p ?o ?g. }

• W224584583 endingPage "3380" @default.
• W224584583 startingPage "3373" @default.
• W224584583 abstract "Biologic responses to cytokines are mediated by intracellular pathways involving induction of signaling and metabolic cascades. Interferon (IFN) regulatory factor-1 (IRF-1) is a major transcription factor induced not only by IFN-gamma but also by other cytokines including tumor necrosis factor-alpha (TNF-alpha). Possible IRF-1 binding sequence elements have been located in the promoter regions of several genes, including p53, inducible nitric oxide synthase, and cyclin D1. IFN-gamma and TNF-alpha can inhibit hematopoiesis in vitro and have been implicated in the pathophysiology of bone marrow (BM) failure. We investigated whether the inhibitory effects of these cytokines were intracellularly mediated through the expression of IRF-1 or -2 in target cells. In total BM cells, IRF-1 mRNA expression increased after stimulation with IFN-gamma and TNF-alpha; the stronger effect was observed with IFN-gamma. In contrast, IRF-2 mRNA expression was constitutive and not altered by cytokine stimulation. By gene amplification, low levels of IRF-1 mRNA were present in unstimulated, highly purified CD34+ cells; on exposure to IFN-gamma and TNF-alpha, amplified IRF-1 mRNA showed a much stronger signal than control. When CD34+ cells were treated with IFN-gamma and TNF-alpha, IRF-1 antisense oligodeoxynucleotide (ODN) partially reversed the suppressive effects on CD34+ cell-derived colony formation by IFN-gamma but not those by TNF-alpha. In parallel experiments, IRF-1 antisense ODN decreased both IRF-1 protein and mRNA expression. The effects of ODN were sequence- specific and concentration-dependent. These results suggest that the inhibitory hematopoietic effects of IFN-gamma and TNF-alpha are mediated by different pathways. For IFN-gamma, IRF-1 is involved in the activation of cellular genes responsible for IFN-gamma suppressive effects." @default.
• W224584583 created "2016-06-24" @default.
• W224584583 creator A5003951580 @default.
• W224584583 creator A5026122857 @default.
• W224584583 creator A5072063614 @default.
• W224584583 creator A5085974329 @default.
• W224584583 date "1995-11-01" @default.
• W224584583 modified "2023-10-10" @default.
• W224584583 title "Hematopoietic inhibition by interferon-gamma is partially mediated through interferon regulatory factor-1" @default.
• W224584583 cites W1488010611 @default.
• W224584583 cites W1506034405 @default.
• W224584583 cites W1515187929 @default.
• W224584583 cites W1528284784 @default.
• W224584583 cites W1559573167 @default.
• W224584583 cites W1568438452 @default.
• W224584583 cites W1596008313 @default.
• W224584583 cites W163753916 @default.
• W224584583 cites W1794193241 @default.
• W224584583 cites W1836932878 @default.
• W224584583 cites W1857506864 @default.
• W224584583 cites W1880227053 @default.
• W224584583 cites W1962468650 @default.
• W224584583 cites W1973293243 @default.
• W224584583 cites W1977698865 @default.
• W224584583 cites W1985929162 @default.
• W224584583 cites W1988600618 @default.
• W224584583 cites W1990701793 @default.
• W224584583 cites W2003571729 @default.
• W224584583 cites W2005484362 @default.
• W224584583 cites W2007460330 @default.
• W224584583 cites W2013046512 @default.
• W224584583 cites W2029275361 @default.
• W224584583 cites W2032463909 @default.
• W224584583 cites W2036576687 @default.
• W224584583 cites W2037772620 @default.
• W224584583 cites W2041576624 @default.
• W224584583 cites W2054132042 @default.
• W224584583 cites W2055952888 @default.
• W224584583 cites W2064023432 @default.
• W224584583 cites W2064632541 @default.
• W224584583 cites W2067286503 @default.
• W224584583 cites W2082542052 @default.
• W224584583 cites W2089372467 @default.
• W224584583 cites W2090162429 @default.
• W224584583 cites W2093874299 @default.
• W224584583 cites W2096935938 @default.
• W224584583 cites W2106315019 @default.
• W224584583 cites W2119092109 @default.
• W224584583 cites W2130191484 @default.
• W224584583 cites W2130282385 @default.
• W224584583 cites W2139532093 @default.
• W224584583 cites W2147015711 @default.
• W224584583 cites W2267848767 @default.
• W224584583 cites W2276422019 @default.
• W224584583 cites W2403984936 @default.
• W224584583 cites W2407028798 @default.
• W224584583 cites W2411074463 @default.
• W224584583 cites W2916399933 @default.
• W224584583 cites W79010973 @default.
• W224584583 doi "https://doi.org/10.1182/blood.v86.9.3373.bloodjournal8693373" @default.
• W224584583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7579440" @default.
• W224584583 hasPublicationYear "1995" @default.
• W224584583 type Work @default.
• W224584583 sameAs 224584583 @default.
• W224584583 citedByCount "48" @default.
• W224584583 countsByYear W2245845832012 @default.
• W224584583 countsByYear W2245845832013 @default.
• W224584583 countsByYear W2245845832014 @default.
• W224584583 countsByYear W2245845832015 @default.
• W224584583 countsByYear W2245845832017 @default.
• W224584583 countsByYear W2245845832021 @default.
• W224584583 crossrefType "journal-article" @default.
• W224584583 hasAuthorship W224584583A5003951580 @default.
• W224584583 hasAuthorship W224584583A5026122857 @default.
• W224584583 hasAuthorship W224584583A5072063614 @default.
• W224584583 hasAuthorship W224584583A5085974329 @default.
• W224584583 hasBestOaLocation W2245845831 @default.
• W224584583 hasConcept C104317684 @default.
• W224584583 hasConcept C109159458 @default.
• W224584583 hasConcept C117705580 @default.
• W224584583 hasConcept C136449434 @default.
• W224584583 hasConcept C153911025 @default.
• W224584583 hasConcept C17991360 @default.
• W224584583 hasConcept C203014093 @default.
• W224584583 hasConcept C2778690821 @default.
• W224584583 hasConcept C2780841837 @default.
• W224584583 hasConcept C28328180 @default.
• W224584583 hasConcept C32300475 @default.
• W224584583 hasConcept C502942594 @default.
• W224584583 hasConcept C55493867 @default.
• W224584583 hasConcept C86339819 @default.
• W224584583 hasConcept C86803240 @default.
• W224584583 hasConcept C8891405 @default.
• W224584583 hasConcept C9173399 @default.
• W224584583 hasConcept C95444343 @default.
• W224584583 hasConceptScore W224584583C104317684 @default.
• W224584583 hasConceptScore W224584583C109159458 @default.
• W224584583 hasConceptScore W224584583C117705580 @default.

• next