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- W2245975752 abstract "6605 Background: Telomerase inhibition is a new strategy that might be useful in inducing senescence and growth inhibition (GI) in cancer cells. Antisense oligonucleotides and more recently pharmacological inhibitors have been used in this setting. Candidate drug BIBR1532 is a non-nucleoside inhibitor of h-TERT. In solid tumor cell lines, it induced telomere erosion and GI (Damm K et al, The Embo J, 2001). BIBR1532 has never been tested in hematological cancers. B-cell tumors were chosen due to their marked difference in TL according to germinal center (GC) origin (i.e. GC-derived vs. extra GC-derived) (Ladetto et al ASH meeting 2003 #796). Methods: The extra-GC derived myeloma cell line KMS11 and GC-derived lymphoma cell lines CA46 and DHL16 were cultured in standard conditions ± BIBR1532 (provided by Klaus Damm MD, Boehringer Ingelheim Pharma, Germany). BIBR1532 10 microM was given thrice a week. KMS11, CA46 and DHL16 have been cultured for 7, 5 and 2 months respectively resulting in 80 mitotic division..." @default.
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- W2245975752 date "2004-07-15" @default.
- W2245975752 modified "2023-10-18" @default.
- W2245975752 title "Candidate drug BIBR1532 induces telomere shortening and growth inhibition in lymphoid cell lines" @default.
- W2245975752 doi "https://doi.org/10.1200/jco.2004.22.14_suppl.6605" @default.
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