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- W2246197299 abstract "Diffusion and flow-limited models defined in physiological and anatomical terms have been employed to examine the effects of intrabody mass transfer on extracorporeal treatment efficiency. Three compartment (plasma, interstitial and intracellular fluid) and four compartment, including red blood cells (RBCs), diffusion limited models were applied to measure creatinine (common metabolite) interstitial/intracellular mass transfer coefficients (MTCs), KI, in both normal subjects and maintenance dialysis patients following bolus intravenous injection of 14c-creatinine. Uremic KI's from the three {formula} and four compartment {formula} analyses were found to be higher (p<0.01) than the corresponding normal values {formula}, 4 pool {formula}. These result simply that cells comprising the intracellular pool (other than RBCs) have slightly elevated creatinine membrane permeabilities in the uremic state. A flow-limited four-pool model of the body (blood, visceral, lean and adipose tissues) was used to simulate the effects of both hemodialysis and hemoperfusion on the removal of two commonly abused lipid soluble drugs (glutethimide and pentobarbital) from body tissues. It was found that after accounting for post treatment plasma rebound and subsequent metabolic removal, a 6 hour dialysis (clearance = 50 ml min-1) removes only 3% of the total ingested glutethimide and about 6% of ingested pentobarbital. For hemoperfusion with a four-fold increase in clearance (200 ml min-1) the corresponding figures are 8% and 17%. These data and the very high success rate of good supportive patient management suggest that the use of extracorporeal therapy modes is not warranted in cases of overdose of glutethimide, pentpentobarbital and possibly other drugs." @default.
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- W2246197299 date "1979-01-01" @default.
- W2246197299 modified "2023-09-27" @default.
- W2246197299 title "Physiological Limitations of Extracorporeal Therapy" @default.
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