Matches in SemOpenAlex for { <https://semopenalex.org/work/W2246236807> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2246236807 endingPage "27" @default.
- W2246236807 startingPage "27" @default.
- W2246236807 abstract "Rationale Rhinovirus (RV) infections are a major cause of asthma exacerbations.Circulating immune cells from asthmatics have a decreased capacity toproduce anti-viral interferons (IFNs) such as IFNa and IFNb, though a detailedanalysis of the molecular events responsible has not been undertaken.Aims To compare the molecular pathways controlling IFNa/b synthesis inasthmatic and healthy subjects.Methods Blood mononuclear cells were isolated from 18 healthy donors and18 asthmatics of moderate disease severity, and cultured with RV for 24 h.Components of the Toll-like receptor (TLR), IFN regulatory and NFkb pathwayswere compared at the mRNA and protein level.Results Compared to RV-stimulated cells from healthy donors, cells fromasthmatics exhibited signifi cantly lower expression of IFNb (P l 0.0001), interferonregulatory factors IRF1 (P l 0.001) and IRF7 (P = 0.03), the interferonstimulated genes MxA and OAS (both P l 0.01), and reduced secretion ofIFNa protein (P = 0.005). Induction of IKKa, p65, p52 and p50 and Toll-likereceptor 7 (TLR7) was also reduced in asthma, whereas TLR8 and IRF5expression were similar in both groups, and RelB and cRel were not inducedby RV. These observations could not be attributed to alterations in the numbersof dendritic cell subsets or their baseline expression of TLR7.Conclusions Multiple defi ciencies in innate interferon signalling pathwayswere identifi ed in asthma. Aberrant function of TLR7 and/or IFN regulatoryproteins is likely to be fundamental to the abnormal anti-viral immunityobserved in asthma." @default.
- W2246236807 created "2016-06-24" @default.
- W2246236807 creator A5034776323 @default.
- W2246236807 creator A5035806248 @default.
- W2246236807 creator A5068291843 @default.
- W2246236807 creator A5083340793 @default.
- W2246236807 creator A5090327971 @default.
- W2246236807 date "2012-01-01" @default.
- W2246236807 modified "2023-09-26" @default.
- W2246236807 title "Asthma is associated with multiple deficiencies in anti-viral type I interferon signalling pathways" @default.
- W2246236807 hasPublicationYear "2012" @default.
- W2246236807 type Work @default.
- W2246236807 sameAs 2246236807 @default.
- W2246236807 citedByCount "0" @default.
- W2246236807 crossrefType "journal-article" @default.
- W2246236807 hasAuthorship W2246236807A5034776323 @default.
- W2246236807 hasAuthorship W2246236807A5035806248 @default.
- W2246236807 hasAuthorship W2246236807A5068291843 @default.
- W2246236807 hasAuthorship W2246236807A5083340793 @default.
- W2246236807 hasAuthorship W2246236807A5090327971 @default.
- W2246236807 hasConcept C126322002 @default.
- W2246236807 hasConcept C136449434 @default.
- W2246236807 hasConcept C137061746 @default.
- W2246236807 hasConcept C170493617 @default.
- W2246236807 hasConcept C202751555 @default.
- W2246236807 hasConcept C203014093 @default.
- W2246236807 hasConcept C2522874641 @default.
- W2246236807 hasConcept C2776042228 @default.
- W2246236807 hasConcept C2776178377 @default.
- W2246236807 hasConcept C2776709828 @default.
- W2246236807 hasConcept C2776914184 @default.
- W2246236807 hasConcept C2776966659 @default.
- W2246236807 hasConcept C2779278377 @default.
- W2246236807 hasConcept C2779836521 @default.
- W2246236807 hasConcept C2780545709 @default.
- W2246236807 hasConcept C55493867 @default.
- W2246236807 hasConcept C71924100 @default.
- W2246236807 hasConcept C86803240 @default.
- W2246236807 hasConcept C8891405 @default.
- W2246236807 hasConceptScore W2246236807C126322002 @default.
- W2246236807 hasConceptScore W2246236807C136449434 @default.
- W2246236807 hasConceptScore W2246236807C137061746 @default.
- W2246236807 hasConceptScore W2246236807C170493617 @default.
- W2246236807 hasConceptScore W2246236807C202751555 @default.
- W2246236807 hasConceptScore W2246236807C203014093 @default.
- W2246236807 hasConceptScore W2246236807C2522874641 @default.
- W2246236807 hasConceptScore W2246236807C2776042228 @default.
- W2246236807 hasConceptScore W2246236807C2776178377 @default.
- W2246236807 hasConceptScore W2246236807C2776709828 @default.
- W2246236807 hasConceptScore W2246236807C2776914184 @default.
- W2246236807 hasConceptScore W2246236807C2776966659 @default.
- W2246236807 hasConceptScore W2246236807C2779278377 @default.
- W2246236807 hasConceptScore W2246236807C2779836521 @default.
- W2246236807 hasConceptScore W2246236807C2780545709 @default.
- W2246236807 hasConceptScore W2246236807C55493867 @default.
- W2246236807 hasConceptScore W2246236807C71924100 @default.
- W2246236807 hasConceptScore W2246236807C86803240 @default.
- W2246236807 hasConceptScore W2246236807C8891405 @default.
- W2246236807 hasLocation W22462368071 @default.
- W2246236807 hasOpenAccess W2246236807 @default.
- W2246236807 hasPrimaryLocation W22462368071 @default.
- W2246236807 hasRelatedWork W1574338039 @default.
- W2246236807 hasRelatedWork W1881320175 @default.
- W2246236807 hasRelatedWork W2016675332 @default.
- W2246236807 hasRelatedWork W2117253480 @default.
- W2246236807 hasRelatedWork W2148907012 @default.
- W2246236807 hasRelatedWork W2162545931 @default.
- W2246236807 hasRelatedWork W2163635921 @default.
- W2246236807 hasRelatedWork W2243468349 @default.
- W2246236807 hasRelatedWork W2256158091 @default.
- W2246236807 hasRelatedWork W2557293209 @default.
- W2246236807 hasRelatedWork W2563631510 @default.
- W2246236807 hasRelatedWork W2579161031 @default.
- W2246236807 hasRelatedWork W2750543912 @default.
- W2246236807 hasRelatedWork W2891325225 @default.
- W2246236807 hasRelatedWork W2990020473 @default.
- W2246236807 hasRelatedWork W2991546162 @default.
- W2246236807 hasRelatedWork W3090528168 @default.
- W2246236807 hasRelatedWork W3106927797 @default.
- W2246236807 hasRelatedWork W3130949281 @default.
- W2246236807 hasRelatedWork W3186529373 @default.
- W2246236807 hasVolume "17" @default.
- W2246236807 isParatext "false" @default.
- W2246236807 isRetracted "false" @default.
- W2246236807 magId "2246236807" @default.
- W2246236807 workType "article" @default.