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- W2246294269 abstract "The principal aim of this study was to explore associations between systemic inflammatory status and periodontal inflammation and tissue destruction. The study population consisted of 61 patients with chronic periodontitis, 30 periodontally healthy control subjects, and 80 subjects with type 1 diabetes mellitus (T1DM). The T1DM subjects were periodontally treated and re-examined eight weeks after completion of the treatment. The periodontal measures included plaque, probing depth (PD), bleeding on probing (BOP) and attachment level (AL). The serum levels of interleukin (IL)6, tumor necrosis factor (TNF)-α, and interleukin (IL)-10, as well as the gingival crevicular fluid (GCF) level of matrix metalloproteinase (MMP)-8 were analyzed using commercially available ELISA assays, and serum high density lipoprotein (HDL) level using direct enzymatic methods. Serum IL-6 level associated significantly with the extent of inflamed periodontal pockets in T1DM subjects. Moreover, serum IL-6 modulated local periodontal inflammation in T1DM patients; periodontal healing turned out to be poorer in subjects with a high level of serum IL-6 than in those with a low level. Serum TNF-α/IL-10 ratio was three times higher in chronic periodontitis patients than in periodontally healthy control subjects. In T1DM subjects a significant inverse association between serum HDL level and the extent of inflamed periodontal pockets was found; subjects with a low serum HDL level presented 50% more inflamed periodontal sites than subjects with a high serum HDL level. A significant association between GCF MMP-8 level in shallow crevices and the extent of periodontal attachment loss in chronic periodontitis patients was observed. In conclusion, we focused on analyzing associations between systemic inflammatory status and periodontal conditions. According to our results, periodontal inflammation/infection is associated with systemic inflammatory status using serum IL-6, TNF-α/IL-10 ratio and HDL as indicators. Also, a high level of MMP-8 in GCF in shallow crevices could be indicative of higher susceptibility to periodontal infection and tissue destruction." @default.
- W2246294269 created "2016-06-24" @default.
- W2246294269 creator A5006855375 @default.
- W2246294269 date "2012-01-01" @default.
- W2246294269 modified "2023-09-26" @default.
- W2246294269 title "Association between periodontal and systemic inflammation : a study of pro- and anti-inflammatory mediators" @default.
- W2246294269 cites W1484199957 @default.
- W2246294269 cites W1508167383 @default.
- W2246294269 cites W1515994079 @default.
- W2246294269 cites W1519919967 @default.
- W2246294269 cites W1520869594 @default.
- W2246294269 cites W1526439198 @default.
- W2246294269 cites W1527315282 @default.
- W2246294269 cites W1532091886 @default.
- W2246294269 cites W1533630422 @default.
- W2246294269 cites W1566992315 @default.
- W2246294269 cites W1571233991 @default.
- W2246294269 cites W1576984763 @default.
- W2246294269 cites W157721590 @default.
- W2246294269 cites W1578606146 @default.
- W2246294269 cites W1580022062 @default.
- W2246294269 cites W1661544713 @default.
- W2246294269 cites W1699917634 @default.
- W2246294269 cites W1823745661 @default.
- W2246294269 cites W1855737037 @default.
- W2246294269 cites W1895277992 @default.
- W2246294269 cites W1905733696 @default.
- W2246294269 cites W1938414864 @default.
- W2246294269 cites W1948454332 @default.
- W2246294269 cites W1963954653 @default.
- W2246294269 cites W1966030851 @default.
- W2246294269 cites W1966213291 @default.
- W2246294269 cites W1966448261 @default.
- W2246294269 cites W1968774460 @default.
- W2246294269 cites W1971162837 @default.
- W2246294269 cites W1971890973 @default.
- W2246294269 cites W1974912234 @default.
- W2246294269 cites W1975444068 @default.
- W2246294269 cites W1976102373 @default.
- W2246294269 cites W1977712559 @default.
- W2246294269 cites W1981920188 @default.
- W2246294269 cites W1982922581 @default.
- W2246294269 cites W1983590269 @default.
- W2246294269 cites W1984035854 @default.
- W2246294269 cites W1984748165 @default.
- W2246294269 cites W1986786856 @default.
- W2246294269 cites W1987150557 @default.
- W2246294269 cites W1987431872 @default.
- W2246294269 cites W1988613128 @default.
- W2246294269 cites W1993999163 @default.
- W2246294269 cites W1998378885 @default.
- W2246294269 cites W1998645118 @default.
- W2246294269 cites W1999443594 @default.
- W2246294269 cites W2001492139 @default.
- W2246294269 cites W2001821836 @default.
- W2246294269 cites W2002727339 @default.
- W2246294269 cites W2002809436 @default.
- W2246294269 cites W2003272988 @default.
- W2246294269 cites W2003423562 @default.
- W2246294269 cites W2006619058 @default.
- W2246294269 cites W2008447801 @default.
- W2246294269 cites W2011128646 @default.
- W2246294269 cites W2013203343 @default.
- W2246294269 cites W2013917284 @default.
- W2246294269 cites W2014093769 @default.
- W2246294269 cites W2014732115 @default.
- W2246294269 cites W2015116686 @default.
- W2246294269 cites W2015339291 @default.
- W2246294269 cites W2015490405 @default.
- W2246294269 cites W2015534647 @default.
- W2246294269 cites W2017220577 @default.
- W2246294269 cites W2017783779 @default.
- W2246294269 cites W2017937067 @default.
- W2246294269 cites W2018526657 @default.
- W2246294269 cites W2019216363 @default.
- W2246294269 cites W2020361370 @default.
- W2246294269 cites W2021274912 @default.
- W2246294269 cites W2022901323 @default.
- W2246294269 cites W2023976647 @default.
- W2246294269 cites W2024967858 @default.
- W2246294269 cites W2027928457 @default.
- W2246294269 cites W2029157767 @default.
- W2246294269 cites W2029957743 @default.
- W2246294269 cites W2032983504 @default.
- W2246294269 cites W2033538734 @default.
- W2246294269 cites W2036895649 @default.
- W2246294269 cites W2036932056 @default.
- W2246294269 cites W2038679742 @default.
- W2246294269 cites W2040750127 @default.
- W2246294269 cites W2041506422 @default.
- W2246294269 cites W2044437167 @default.
- W2246294269 cites W2044720356 @default.
- W2246294269 cites W2045264957 @default.
- W2246294269 cites W2045568806 @default.
- W2246294269 cites W2049171199 @default.
- W2246294269 cites W2050156689 @default.
- W2246294269 cites W2050390830 @default.
- W2246294269 cites W2052462816 @default.
- W2246294269 cites W2052992473 @default.
- W2246294269 cites W2054719874 @default.