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- W2246362911 abstract "Over the last decade there has been an increase in the understanding of the regulate factors in the tumor progression and metastasis formation. In an attempt to understand metastases formation as a “systemic” event of cancer, several authors have reported the role of Bone Marrow (BM) derived cells in inducing primary tumor angiogenesis and also in the formation of the pre-metastatic niche. The main objective of this thesis was to investigate the factors that regulate the expression of Jagged-2. Jagged-2 is a transmembrane protein and it is a ligand of the Notch signaling pathway, required for embryonic development, the regulation of tissue homeostasis, and the maintenance of stem cells in adults. The Notch pathway has multiple roles in cell fate specification, tissue patterning, and morphogenesis through effects on differentiation, proliferation, survival, and apoptosis. An interesting aspect of the Notch pathway are it apparently opposite functions in tumor development, because it can act as an oncogene or as a tumor suppressor. In many individuals, the endpoint of multistep tumor progression involves, unfortunately, the acquisition by cancer cells of the ability to invade and to metastasize from the primary tumor to distant sites in the body the manifestations of high-grade malignancy. One of the major processes regulating local invasion in epithelial tumors is termed Epithelial to Mesenchymal Transition (EMT) which is associated with the acquisition of mesenchymal phenotype, which is accompanied by the loss of epithelial marker expression and up-regulation of mesenchymal molecular markers. Through the expression of Jagged 2 ligand of Notch pathway involved in junction cell-to-cell and consequently the formation of metastases, we studied the factors involved in the expression of Jagged 2. Our findings suggested that hypoxia-induced CoCl2 in leukemic cells regulates the expression of Jagged2 and that the absence of the FBS also regulates the expression of Jagged2. Using both by qRT-PCR and flow cytometry methods, differences in the expression levels of Jagged 2 were found in peripheral and umbilical cord bloods of healthy people. This could be a starting point for a viable strategy for treatment and new targeted therapies." @default.
- W2246362911 created "2016-06-24" @default.
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- W2246362911 date "2013-01-01" @default.
- W2246362911 modified "2023-09-27" @default.
- W2246362911 title "Study of the factors that regulate the expression of Jagged-2" @default.
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- W2246362911 hasPublicationYear "2013" @default.
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