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• W2246366833 abstract "The objectives of the present study was to determine the concentration of angiotensin II (AngII) in follicular fluid, to characterize the expression of renin-angiotensin system (RAS) genes in follicular cells and to verify the role of AngII in the follicular wave, using an in vivo model with intrafollicular injection and in vitro model with granulosa cells culture. AngII concentration in follicular fluid increased on dominant follicle during and after deviation. Saralasin inhibited follicular growth in all treated cows (4/4), suggesting that AngII is essential for follicular growth in 7-8mm follicles. However, intrafollicular injection of AngII affected neither follicular growth nor the pattern of follicular dynamics, which were similar to control cows. These results imply that bovine ovarian follicles contain sufficient AngII for follicle development. In another experiment, saralasin inhibitory effect was overcome by systemic FSH supplementation, suggesting that AngII is essential to follicular growth during FSH-low dependence stages. The injection of AngII or angiotensin receptor type 2 (AGTR2) agonist in second largest follicle prevented the expected atresia of subordinate follicle and the treated follicle grew at the same rate as the dominant during 24h. To understand why a single intrafollicular injection of AngII antagonist induces follicular atresia, dominant follicle was injected with saralasin or saline and the cows were ovariectomized 24h later. The inhibition of AngII action decreased estradiol concentration in follicular fluid and abundance of mRNA encoding aromatase (CYP19), 3!-hydroxysteroid dehydrogenase (3!HSD), LH receptor, SerpinE2 and cyclinD2 in granulosa cells. On granulosa cell culture, AngII increased CYP19 expression just in the presence of FSH. Taken together, these results show that AngII is essential for follicular growth, and plays important role in regulating genes involved in granulosa cell proliferation (cyclinD2) and differentiation (LHr, aromatase, 3!HSD), which are necessary for development of the dominant follicle. In conclusion, these data suggest that AngII signaling is involved in follicle growth and dominance in cattle.%%%%Os objetivos do presente trabalho foram determinar a concentracao de angiotensina II (AngII) no fluido folicular, caracterizar a expressao dos genes do sistema renina-angiotensina (RAS) nas celulas foliculares e verificar o papel da AngII na onda folicular, utilizando um modelo in vivo de injecao intrafolicular e in vitro de cultivo de celulas da granulosa. A concentracao de AngII no fluido folicular aumentou no foliculo de maior diâmetro, durante e apos a divergencia folicular. A administracao intrafolicular de saralasina, um bloqueador competitivo dos receptores de AngII, inibiu o crescimento folicular em todas as vacas injetadas (4/4), demonstrando que a AngII e essencial para o crescimento de foliculos de 7-8mm de diâmetro. Contudo, a injecao de AngII nao afetou o crescimento folicular, sugerindo que os foliculos contem AngII suficiente para o seu…" @default.
• W2246366833 created "2016-06-24" @default.
• W2246366833 creator A5009093956 @default.
• W2246366833 date "2010-03-02" @default.
• W2246366833 modified "2023-09-22" @default.
• W2246366833 title "Ação da angiotensina II na regulação da dominância folicular em bovinos" @default.
• W2246366833 cites W1481710938 @default.
• W2246366833 cites W1563090311 @default.
• W2246366833 cites W1605779041 @default.
• W2246366833 cites W165523100 @default.
• W2246366833 cites W1821554906 @default.
• W2246366833 cites W1855562907 @default.
• W2246366833 cites W1869279141 @default.
• W2246366833 cites W1968309322 @default.
• W2246366833 cites W1974832873 @default.
• W2246366833 cites W1975626496 @default.
• W2246366833 cites W1978223366 @default.
• W2246366833 cites W1979149434 @default.
• W2246366833 cites W1983251645 @default.
• W2246366833 cites W1986652739 @default.
• W2246366833 cites W1990191901 @default.
• W2246366833 cites W1996456727 @default.
• W2246366833 cites W1999095690 @default.
• W2246366833 cites W2002827798 @default.
• W2246366833 cites W2004146174 @default.
• W2246366833 cites W2006822228 @default.
• W2246366833 cites W2008626148 @default.
• W2246366833 cites W2009646949 @default.
• W2246366833 cites W2011356158 @default.
• W2246366833 cites W2011713635 @default.
• W2246366833 cites W2017800047 @default.
• W2246366833 cites W2019805937 @default.
• W2246366833 cites W2020192585 @default.
• W2246366833 cites W2022244349 @default.
• W2246366833 cites W2028439883 @default.
• W2246366833 cites W2030331836 @default.
• W2246366833 cites W2035102780 @default.
• W2246366833 cites W2035403324 @default.
• W2246366833 cites W2039912643 @default.
• W2246366833 cites W2044112537 @default.
• W2246366833 cites W2045907417 @default.
• W2246366833 cites W2050325550 @default.
• W2246366833 cites W2050836208 @default.
• W2246366833 cites W2052465225 @default.
• W2246366833 cites W2054409489 @default.
• W2246366833 cites W2060061982 @default.
• W2246366833 cites W2060515743 @default.
• W2246366833 cites W2060555867 @default.
• W2246366833 cites W2065030826 @default.
• W2246366833 cites W2066299890 @default.
• W2246366833 cites W2069191696 @default.
• W2246366833 cites W2070374666 @default.
• W2246366833 cites W2076466120 @default.
• W2246366833 cites W2080951265 @default.
• W2246366833 cites W2086209335 @default.
• W2246366833 cites W2090885342 @default.
• W2246366833 cites W2092171289 @default.
• W2246366833 cites W2092288331 @default.
• W2246366833 cites W2096352923 @default.
• W2246366833 cites W2100131969 @default.
• W2246366833 cites W2106996349 @default.
• W2246366833 cites W2107277218 @default.
• W2246366833 cites W2110134466 @default.
• W2246366833 cites W2112676434 @default.
• W2246366833 cites W2114226305 @default.
• W2246366833 cites W2115787462 @default.
• W2246366833 cites W2120390384 @default.
• W2246366833 cites W2122639201 @default.
• W2246366833 cites W2133843070 @default.
• W2246366833 cites W2135439806 @default.
• W2246366833 cites W2136117114 @default.
• W2246366833 cites W2137497217 @default.
• W2246366833 cites W2138714285 @default.
• W2246366833 cites W2139181447 @default.
• W2246366833 cites W2140137540 @default.
• W2246366833 cites W2143688944 @default.
• W2246366833 cites W2146867563 @default.
• W2246366833 cites W2147404179 @default.
• W2246366833 cites W2150975625 @default.
• W2246366833 cites W2153063244 @default.
• W2246366833 cites W2153595186 @default.
• W2246366833 cites W2156449575 @default.
• W2246366833 cites W2156708399 @default.
• W2246366833 cites W2158418700 @default.
• W2246366833 cites W2159022420 @default.
• W2246366833 cites W2159129772 @default.
• W2246366833 cites W2162486306 @default.
• W2246366833 cites W2166822914 @default.
• W2246366833 cites W2168075403 @default.
• W2246366833 cites W2169507804 @default.
• W2246366833 cites W2175038089 @default.
• W2246366833 cites W2265355159 @default.
• W2246366833 cites W2319658883 @default.
• W2246366833 cites W2410712514 @default.
• W2246366833 cites W2595269908 @default.
• W2246366833 cites W2915150600 @default.
• W2246366833 cites W3150019474 @default.
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