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• W2246397136 abstract "Iron is an essential nutrient for all mammalian cells, and numerous proteins are dedicated to the uptake and distribution of iron within cells. As discussed in previous chapters, there are proteins that facilitate iron uptake, including transferrin receptors 1 and 2 (TfR1 and TfR2) [1] and DMT1 [2], proteins dedicated to iron storage, including ferritin H and L chains [3, 4], and an iron exporter, ferroportin [5, 6]. Most cellular proteins are synthesized in the cytosol and those that require an iron cofactor generally acquire their iron from the cytosolic iron pool. The nature of the cytosolic iron pool remains uncharacterized, as the iron is not associated with a specific known iron carrier molecule. The iron in this accessible iron pool may be bound with low affinity to abundant negatively charged molecules, including citrate and ATP. Because the cytosol of cells is a reducing environment, most cellular iron is likely in the ferrous (Fe2+) rather than in the ferric (Fe3+) state. Iron that enters the endosome in the transferrin cycle is initially in the ferric state, but an endosomal reductase, Steap3 [7], reduces it to ferrous iron, the form that is transported into cytosol by DMT1. When iron is taken up by ferritin, it is oxidized by ferroxidase activity of the ferritin H chain [3, 4], which facilitates precipitation and storage of iron in the ferritin heteropolymer." @default.
• W2246397136 created "2016-06-24" @default.
• W2246397136 creator A5017226392 @default.
• W2246397136 date "2011-11-24" @default.
• W2246397136 modified "2023-10-18" @default.
• W2246397136 title "Regulation of Iron Metabolism in Mammalian Cells" @default.
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• W2246397136 cites W1502521862 @default.
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• W2246397136 cites W1522274444 @default.
• W2246397136 cites W1530657831 @default.
• W2246397136 cites W153290133 @default.
• W2246397136 cites W1967855521 @default.
• W2246397136 cites W1969296748 @default.
• W2246397136 cites W1970266451 @default.
• W2246397136 cites W1979091103 @default.
• W2246397136 cites W1985431208 @default.
• W2246397136 cites W1985841747 @default.
• W2246397136 cites W1991421091 @default.
• W2246397136 cites W1995295757 @default.
• W2246397136 cites W1998351143 @default.
• W2246397136 cites W1998851985 @default.
• W2246397136 cites W2007919022 @default.
• W2246397136 cites W2008376250 @default.
• W2246397136 cites W2015248217 @default.
• W2246397136 cites W2016786613 @default.
• W2246397136 cites W2017107298 @default.
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• W2246397136 cites W2031212222 @default.
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• W2246397136 doi "https://doi.org/10.1007/978-1-60327-485-2_3" @default.
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