FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2246486415> ?p ?o ?g. }

• W2246486415 abstract "Serous papillary endometrial cancers (SPEC) harboring several genetic alterations, such as TP53 mutation, are known highly progressive with worse prognosis compared with endometrioid counter-part, but it still remains unclear which molecular pathway is responsible for their unfavorable features. The IFN-γ; transcription factor signal transducer and activator of transcription 1 (STAT1) has been considered as a tumor suppressor with transcription-dependent and transcription-independent mechanisms, but recent studies showed STAT1 was associated with poor prognosis, and was involved in maintaining basal expression of tumor pro-survival STAT3 target genes, such as MYC, with unclear mechanism in some cancers. A previous report of the cancer genome atlas (TCGA) indicated MYC amplification in some SPECs; as MYC is known to be maintained also by STAT1, we investigate the role of STAT1-MYC axis in the malignant features of SPECs. Gene expression microarray was conducted for 63 endometrial cancer samples and SPEC cell line, SPAC-1L. Immunohistochemical staining were conducted using endometrial cancer samples under protocols approved by the Institutional Review Board to investigate SPEC-specific pathways (Kyoto cohort: n=91, Vancouver cohort: n=462). Using SPAC-1L cell line, several functional assay in vitro such as cellular proliferation, migration, invasion and apoptosis under treatment of cisplatin, doxorubicin, and paclitaxel were assessed with or without suppressing target genes. In vivo tumorigenesis was performed in mouse model and some computational analysis were done in silico. Gene expression microarray analysis revealed STAT1 pathway was commonly activated in SPECs both in our dataset and TCGA dataset as a key molecule of ‘SPEC signature’. In two independent cohorts, STAT1 expression was confirmed significantly higher in SPECs (p These results indicate that STAT1 pathway modulates the micro-environment of SPECs in deregulating MYC, as well as other target genes, to promote tumor progression. Furthermore, STAT1-MYC axis could be developed as a novel potential target for molecular targeting therapy in SPECs. Citation Format: Budiman Kharma, Tsukasa Baba, Noriomi Matsumura, Ryusuke Murakami, Ken Yamaguchi, Junzo Hamanishi, Masaki Mandai, Ikuo Konishi. Dysregulation of MYC via STAT1 promotes tumor progression in serous papillary endometrial cancer. [abstract]. In: Proceedings of the AACR Special Conference on Myc: From Biology to Therapy; Jan 7-10, 2015; La Jolla, CA. Philadelphia (PA): AACR; Mol Cancer Res 2015;13(10 Suppl):Abstract nr A25." @default.
• W2246486415 created "2016-06-24" @default.
• W2246486415 creator A5006506867 @default.
• W2246486415 creator A5023191265 @default.
• W2246486415 creator A5028817103 @default.
• W2246486415 creator A5035369794 @default.
• W2246486415 creator A5036589972 @default.
• W2246486415 creator A5051800836 @default.
• W2246486415 creator A5082910812 @default.
• W2246486415 creator A5088883992 @default.
• W2246486415 date "2015-10-01" @default.
• W2246486415 modified "2023-09-25" @default.
• W2246486415 title "Abstract A25: Dysregulation of MYC via STAT1 promotes tumor progression in serous papillary endometrial cancer" @default.
• W2246486415 doi "https://doi.org/10.1158/1557-3125.myc15-a25" @default.
• W2246486415 hasPublicationYear "2015" @default.
• W2246486415 type Work @default.
• W2246486415 sameAs 2246486415 @default.
• W2246486415 citedByCount "0" @default.
• W2246486415 crossrefType "proceedings-article" @default.
• W2246486415 hasAuthorship W2246486415A5006506867 @default.
• W2246486415 hasAuthorship W2246486415A5023191265 @default.
• W2246486415 hasAuthorship W2246486415A5028817103 @default.
• W2246486415 hasAuthorship W2246486415A5035369794 @default.
• W2246486415 hasAuthorship W2246486415A5036589972 @default.
• W2246486415 hasAuthorship W2246486415A5051800836 @default.
• W2246486415 hasAuthorship W2246486415A5082910812 @default.
• W2246486415 hasAuthorship W2246486415A5088883992 @default.
• W2246486415 hasConcept C104317684 @default.
• W2246486415 hasConcept C121608353 @default.
• W2246486415 hasConcept C171958077 @default.
• W2246486415 hasConcept C2777003663 @default.
• W2246486415 hasConcept C2777088508 @default.
• W2246486415 hasConcept C2778923194 @default.
• W2246486415 hasConcept C502942594 @default.
• W2246486415 hasConcept C54355233 @default.
• W2246486415 hasConcept C555283112 @default.
• W2246486415 hasConcept C86339819 @default.
• W2246486415 hasConcept C86803240 @default.
• W2246486415 hasConceptScore W2246486415C104317684 @default.
• W2246486415 hasConceptScore W2246486415C121608353 @default.
• W2246486415 hasConceptScore W2246486415C171958077 @default.
• W2246486415 hasConceptScore W2246486415C2777003663 @default.
• W2246486415 hasConceptScore W2246486415C2777088508 @default.
• W2246486415 hasConceptScore W2246486415C2778923194 @default.
• W2246486415 hasConceptScore W2246486415C502942594 @default.
• W2246486415 hasConceptScore W2246486415C54355233 @default.
• W2246486415 hasConceptScore W2246486415C555283112 @default.
• W2246486415 hasConceptScore W2246486415C86339819 @default.
• W2246486415 hasConceptScore W2246486415C86803240 @default.
• W2246486415 hasLocation W22464864151 @default.
• W2246486415 hasOpenAccess W2246486415 @default.
• W2246486415 hasPrimaryLocation W22464864151 @default.
• W2246486415 hasRelatedWork W1980141404 @default.
• W2246486415 hasRelatedWork W2008705571 @default.
• W2246486415 hasRelatedWork W2034723907 @default.
• W2246486415 hasRelatedWork W2039370099 @default.
• W2246486415 hasRelatedWork W2048809701 @default.
• W2246486415 hasRelatedWork W2081742082 @default.
• W2246486415 hasRelatedWork W2113670025 @default.
• W2246486415 hasRelatedWork W2148748188 @default.
• W2246486415 hasRelatedWork W2326081853 @default.
• W2246486415 hasRelatedWork W2491929412 @default.
• W2246486415 hasRelatedWork W2576171672 @default.
• W2246486415 hasRelatedWork W2593629899 @default.
• W2246486415 hasRelatedWork W2604190952 @default.
• W2246486415 hasRelatedWork W2786123882 @default.
• W2246486415 hasRelatedWork W2794261296 @default.
• W2246486415 hasRelatedWork W279813875 @default.
• W2246486415 hasRelatedWork W2885964858 @default.
• W2246486415 hasRelatedWork W2902464385 @default.
• W2246486415 hasRelatedWork W2921335270 @default.
• W2246486415 hasRelatedWork W3039343971 @default.
• W2246486415 isParatext "false" @default.
• W2246486415 isRetracted "false" @default.
• W2246486415 magId "2246486415" @default.
• W2246486415 workType "article" @default.