FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2246768150> ?p ?o ?g. }

• W2246768150 abstract "The duration of untreated psychosis (DUP) and its association with the course of illness in schizophrenia has been widely addressed, but the conclusions still remain essentially unclear. The studies with unselected samples and longitudinal data are few and needed. The aim of this dissertation was to study DUP and the long-term course of illness in schizophrenia in a metaanalysis and in the Northern Finland 1966 Birth Cohort (NFBC 1966). A meta-analysis of 31 original studies on the long-term association between DUP and clinical and social outcomes showed that long DUP had a small but statistically significant association with poor symptomatic, social, and global outcomes. However, there was no significant correlation between DUP and use of treatment, employment, and quality of life. In the NFBC 1966, the associations between DUP and the outcomes (n=89) were assessed with several measurements of mental and psychical state, treatment factors, education, and ability to work. In the short-term outcome, long DUP was associated with longer first hospitalization and increased risk of re-hospitalization. In the long-term, long DUP was associated only with a decreased rate of disability pension. When the association between DUP and brain structures using magnetic resonance imaging (MRI) was analyzed (n=46), long DUP correlated with decreased gray-matter density in the right hippocampus. DUP may be a modest marker of a more severe clinical phenotype regarding early outcome, but in the NFBC 1966, longer DUP seems to associate with better clinical and occupational outcomes. The relatively modest effect of DUP on outcomes indicates that shortening DUP may have positive effects on the long-term clinical course. However, it is unlikely that early intervention alone could significantly improve the overall long-term outcome of schizophrenia. Early detection of psychosis is one of the possibilities to achieve the improvement, especially in the short-term outcome of schizophrenia." @default.
• W2246768150 created "2016-06-24" @default.
• W2246768150 creator A5064636092 @default.
• W2246768150 date "2013-01-01" @default.
• W2246768150 modified "2023-09-27" @default.
• W2246768150 title "Duration of untreated psychosis : association with clinical and social outcomes and brain morphology in schizophrenia" @default.
• W2246768150 cites W112185801 @default.
• W2246768150 cites W119903107 @default.
• W2246768150 cites W1411265151 @default.
• W2246768150 cites W1483210228 @default.
• W2246768150 cites W1485901143 @default.
• W2246768150 cites W1486770920 @default.
• W2246768150 cites W1500477600 @default.
• W2246768150 cites W1507898056 @default.
• W2246768150 cites W1518890501 @default.
• W2246768150 cites W1530424072 @default.
• W2246768150 cites W1532157360 @default.
• W2246768150 cites W1574253139 @default.
• W2246768150 cites W1687524323 @default.
• W2246768150 cites W171580799 @default.
• W2246768150 cites W174949386 @default.
• W2246768150 cites W1911472948 @default.
• W2246768150 cites W1936079710 @default.
• W2246768150 cites W1940337650 @default.
• W2246768150 cites W1964297795 @default.
• W2246768150 cites W1965509311 @default.
• W2246768150 cites W1965894275 @default.
• W2246768150 cites W1966020199 @default.
• W2246768150 cites W1967717083 @default.
• W2246768150 cites W1967786852 @default.
• W2246768150 cites W1968554800 @default.
• W2246768150 cites W1968928287 @default.
• W2246768150 cites W1968929298 @default.
• W2246768150 cites W1968985105 @default.
• W2246768150 cites W1970308333 @default.
• W2246768150 cites W1970366326 @default.
• W2246768150 cites W1972290754 @default.
• W2246768150 cites W1974944432 @default.
• W2246768150 cites W1977070136 @default.
• W2246768150 cites W1977651488 @default.
• W2246768150 cites W1980125795 @default.
• W2246768150 cites W1980862554 @default.
• W2246768150 cites W1981283014 @default.
• W2246768150 cites W1983192271 @default.
• W2246768150 cites W1983720479 @default.
• W2246768150 cites W1984037815 @default.
• W2246768150 cites W1985661126 @default.
• W2246768150 cites W1985802733 @default.
• W2246768150 cites W1986562944 @default.
• W2246768150 cites W1988580159 @default.
• W2246768150 cites W1988775970 @default.
• W2246768150 cites W1990458825 @default.
• W2246768150 cites W1991816823 @default.
• W2246768150 cites W1992297215 @default.
• W2246768150 cites W1993401922 @default.
• W2246768150 cites W1993739915 @default.
• W2246768150 cites W1993889588 @default.
• W2246768150 cites W1993935607 @default.
• W2246768150 cites W1997031801 @default.
• W2246768150 cites W1997918569 @default.
• W2246768150 cites W1998436401 @default.
• W2246768150 cites W1999591954 @default.
• W2246768150 cites W1999692781 @default.
• W2246768150 cites W1999736787 @default.
• W2246768150 cites W2000342118 @default.
• W2246768150 cites W2000533601 @default.
• W2246768150 cites W2001861241 @default.
• W2246768150 cites W2006017013 @default.
• W2246768150 cites W2007171039 @default.
• W2246768150 cites W2007838768 @default.
• W2246768150 cites W2010327211 @default.
• W2246768150 cites W2011508556 @default.
• W2246768150 cites W2013757355 @default.
• W2246768150 cites W2014462343 @default.
• W2246768150 cites W2014596655 @default.
• W2246768150 cites W2014796841 @default.
• W2246768150 cites W2015063632 @default.
• W2246768150 cites W2015555958 @default.
• W2246768150 cites W2016140755 @default.
• W2246768150 cites W2018054716 @default.
• W2246768150 cites W2018491547 @default.
• W2246768150 cites W2018673662 @default.
• W2246768150 cites W2019465651 @default.
• W2246768150 cites W2021706944 @default.
• W2246768150 cites W2022978173 @default.
• W2246768150 cites W202304088 @default.
• W2246768150 cites W2023187107 @default.
• W2246768150 cites W2024356071 @default.
• W2246768150 cites W2025349254 @default.
• W2246768150 cites W2026913926 @default.
• W2246768150 cites W2027196653 @default.
• W2246768150 cites W2028017622 @default.
• W2246768150 cites W2030396834 @default.
• W2246768150 cites W2031630269 @default.
• W2246768150 cites W2032861045 @default.
• W2246768150 cites W2033483059 @default.
• W2246768150 cites W2033659993 @default.
• W2246768150 cites W2034956884 @default.
• W2246768150 cites W2035082271 @default.
• W2246768150 cites W2036734621 @default.

• next