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- W2246793920 abstract "Lecture delivered on July 9th, 2009, on the occasion of ISNA at Kolkata * Department of Zoology, University of Delhi, Delhi-110007 # E-mail : kambadur@hotmail.com Nutritional studies on humans and animals have long back established the role of vitamins and mineral elements in health1. For many phylogenic groups these are essential i.e. they have to be supplied in the diet as, such organisms like humans have lost the ability to biosynthesize these dietary components. While a lot of biochemical work has been done on the dietary carbohydrate, protein and lipid metabolism in generating, storing and utilizing energy for living processes2, the metabolic link between the biochemical reaction in which the vitamin takes part and the disease precipitated in their absence is not clearly understood. This is true for many genetic disorders also where establishing cause and effect metabolic link between gene defect and a phenotype like mental disorder is proving to be difficult. Reproduction in higher animals is a complex physiological process resulting in progeny generation3. Vitamins like vitamin E (alpha tocopherol) are essential for successful reproduction in many higher animals4. Other vitamins like ascorbic acid, riboflavin, niacin and thiamine directly or indirectly are required for reproductive success. In oviparous animals, these vitamins are supplied by the female adult through the egg yolk to the new generation during development5. But during the adult stage, they have to be obtained through diet. Reproductive hormones of pituitary and gonadal origin regulate many reproductive physiological processes6,7. One of the known actions of the pituitary luteinizing hormone (LH) is to cause depletion of the ovarian ascorbic acid content and this in effect forms the basis of a reliable bioassay for this hormone7. What is not known clearly is the mechanism by which this depletion is brought about. In animals like rats and mice, it could be envisaged that LH must be affecting, either the biosynthesis or catabolism or both, of ascorbic acid in the ovary. The famous 'Parlow rat' is the experimental model to demonstrate this bioassay. Briefly 25-26 day old immature rats of Holtzman or any other strain are administered Pregnant Mare Serum Gonadotrophin (PMSG) and human Chorionic Gonadotrophin (hCG) in sequence to accelerate ovarian follicular growth (hyperplasia and hypertrophy) and induce super ovulation (Fig 1)." @default.
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- W2246793920 date "2009-01-01" @default.
- W2246793920 modified "2023-09-28" @default.
- W2246793920 title "L-GULONATE DEHYDROGENASE : A COMMON REGULATORY TARGET IN DIABETIC NEPHROPATHY, RETINOPATHY, AND IN OVARIAN FUNCTION" @default.
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