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- W2246981475 abstract "2077 Background: We have previously shown that the cytosine analog CS-682 is active in orthotopic metastatic nude mouse models of human pancreatic cancer. The current study evaluates CS-682 in a novel adjuvant-treatment orthotopic nude mouse model of human pancreatic cancer with efficacy visualized in real-time with fluorescence imaging. Methods: Seven days after implantation, mice were randomized into eight groups, depending on whether they were to be treated by tumor resection, five weeks of CS-682 chemotherapy at 40–60 mg/kg qd or both. Throughout the course of treatment, non-invasive optical whole-body imaging based on brilliant red fluorescent protein (RFP) expression of the tumor permitted visualization and quantification of primary, metastatic, and recurrent disease. Results: Total tumor burden negatively correlated with survival. Untreated mice died of disseminated disease with a median survival of 26 days. Surgical resection alone conferred a small but significant survival advantage (median survi..." @default.
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- W2246981475 date "2004-07-15" @default.
- W2246981475 modified "2023-09-25" @default.
- W2246981475 title "Survival efficacy of adjuvant cytosine-analog CS-682 in a fluorescent orthotopic model of human pancreatic cancer" @default.
- W2246981475 doi "https://doi.org/10.1200/jco.2004.22.14_suppl.2077" @default.
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