Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247012228> ?p ?o ?g. }
- W2247012228 abstract "Actinobacillus succinogenes is a promising bacterial catalyst for the bioproduction of succinic acid from low-cost raw materials. In this work, a genome-scale metabolic model was reconstructed and used to assess the metabolic capabilities of this microorganism under producing conditions.The model, iBP722, was reconstructed based on the functional reannotation of the complete genome sequence of A. succinogenes 130Z and manual inspection of metabolic pathways, covering 1072 enzymatic reactions associated with 722 metabolic genes that involve 713 metabolites. The highly curated model was effective in capturing the growth of A. succinogenes on various carbon sources, as well as the SA production under various growth conditions with fair agreement between experimental and predicted data. Calculated flux distributions under different conditions show that a number of metabolic pathways are affected by the activity of some metabolic enzymes at key nodes in metabolism, including the transport mechanism of carbon sources and the ability to fix carbon dioxide.The established genome-scale metabolic model can be used for model-driven strain design and medium alteration to improve succinic acid yields." @default.
- W2247012228 created "2016-06-24" @default.
- W2247012228 creator A5002874757 @default.
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- W2247012228 creator A5079343705 @default.
- W2247012228 creator A5079452731 @default.
- W2247012228 creator A5085847301 @default.
- W2247012228 date "2018-05-30" @default.
- W2247012228 modified "2023-10-18" @default.
- W2247012228 title "Reconstruction of a genome-scale metabolic model for Actinobacillus succinogenes 130Z" @default.
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- W2247012228 doi "https://doi.org/10.1186/s12918-018-0585-7" @default.
- W2247012228 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5975692" @default.
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- W2247012228 hasPublicationYear "2018" @default.
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