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• W2247061344 endingPage "3007" @default.
• W2247061344 startingPage "2999" @default.
• W2247061344 abstract "Zhang, Y., P. L. Carlen, and L. Zhang. Kinetics of muscarinic reduction of I sAHP in hippocampal neurons: effects of acetylcholinesterase inhibitors. J. Neurophysiol. 78: 2999–3007, 1997. The present experiments were designed to elucidate the time frame in which an evoked cholinergic impulse decreases the Ca 2+ -dependent K + current ( I sAHP ) in hippocampal CA1 neurons, and to determine to what extent acetylcholinesterase (AChE) inhibitors enhance the efficacy of the cholinergic impulse. Whole cell voltage-clamp recordings were performed on hippocampal CA1 neurons of rat brain slices and I sAHP s were evoked by constant depolarizing pulses. Cholinergic afferent fibers in stratum oriens were stimulated electrically and the time interval between the afferent stimulus and the depolarizing pulse was varied from 1 to 30 s. In slices perfused with the standard external medium, the afferent stimulus caused a profound decrease in the following I sAHP only when the stimulus preceded the depolarizing pulse by 1–2 s. The stimulus was without effects on the I sAHP when applied ≥5s before the depolarizing pulse. The effects of the afferent stimulus were greatly enhanced in CA1 neurons exposed to the catalytic AChE inhibitors neostigmine, physostigmine, or 9-amino-1,2,3,4-tetrahydro-acridine. A substantial decrease in the I sAHP was observed even when the stimulus preceded the depolarizing pulse by ≥30 s. However applications of peripheral site AChE inhibitors decamethonium and propidium caused only minor or no enhancement of the I sAHP reduction after the afferent stimulus. We suggest in physiological conditions that muscarinic modulation of ionic conductances of CNS neurons has a limited time course after a cholinergic impulse and that the modulation is greatly enhanced and prolonged when catalytic activities of AChEs are suppressed pharmacologically." @default.
• W2247061344 created "2016-06-24" @default.
• W2247061344 creator A5044113968 @default.
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• W2247061344 date "1997-12-01" @default.
• W2247061344 modified "2023-09-27" @default.
• W2247061344 title "Kinetics of Muscarinic Reduction of <i>I</i> _sAHP in Hippocampal Neurons: Effects of Acetylcholinesterase Inhibitors" @default.
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• W2247061344 doi "https://doi.org/10.1152/jn.1997.78.6.2999" @default.
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