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- W22471006 endingPage "452" @default.
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- W22471006 abstract "Major advances in the use of carrier vehicles delivering pharmacologic agents and enzymes to sites of disease have occurred in the past 10 years. This chapter focuses on the concepts and preclinical as well as clinical evaluation of carrier-mediated anticancer agents that are administered intravenously or orally. The primary types of carrier-mediated anticancer agents are nanoparticles, nanosomes, which are nanoparticle sized liposomes, and conjugated agents. Nanosomes are then subdivided into stabilized and nonstabilized or conventional nanosomes. The theoretical advantages of carrier-mediated drugs are increased solubility, prolonged duration of exposure, selective delivery of entrapped drug to the site of action, improved therapeutic index, and potential to overcome resistance to anticancer agents. The disposition of carrier-mediated agents depends on the physiochemical characteristics of the carrier, such as size, surface charge, membrane lipid packing, steric stabilization, dose, and route of administration. The primary sites of accumulation of carrier-mediated agents are the tumor, liver, and spleen compared to nonnanosomal formulations. The factors affecting the pharmacokinetic and pharmacodynamic variability of these agents remain unclear, but most likely include the reticuloendothelial system (RES), which has also been called the mononuclear phagocyte system (MPS). As existing anticancer agents go off patent, these agents will most likely be evaluated in some type of carrier-mediated formulation. Future studies need to evaluate clearance mechanisms of carrier-mediated agents to identify the factors associated with pharmacokinetic and pharmacodynamic variability in patients and specifically in tumors. However, carrier-mediated anticancer agents represent a promising platform for the targeted delivery of antitumor therapy." @default.
- W22471006 created "2016-06-24" @default.
- W22471006 creator A5025588314 @default.
- W22471006 creator A5085654922 @default.
- W22471006 date "2011-10-21" @default.
- W22471006 modified "2023-09-25" @default.
- W22471006 title "Carrier-Mediated and Targeted Cancer Drug Delivery" @default.
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