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- W2247121040 abstract "The steroid hormone progesterone is considered indisPensiblefor pregnancy - it is the 'hormone of pregnancy' as describedby corner (1928). It is generally agreed that the role ofprogesterone in all species is to Prepare the endometrium forpregnancy and to contribute to the maintenance of myometrialquiescence from implantation to the end of Pregnancy. Thereis however, a conflict of opinion concerning its role inpregnancy termination. In some species, for example thesheep, there is considerable evidence that progesteroneprovides an important link between fetal cortisol and thecontrol of uterine activity. But in human pregnancy theevidence is conflicting.The present study investigates the role of progesterone inthe initiation of uterine activity in;- late pregnant ehtes,- early human pregnancy and- the luteal phase of the human menstrual cycIe.The study was designed following the development of a3 B-nyaroxysteroid dehydrogenase (3 B-ttso) inhibitor(Epostane) by Sterling Winthrop Research. In vitro,Epostane acts comPetitively to inhibit the conversion ofpregnenolone to Progesterone. This provides a method ofinvestigating the role of Progesterone in the classicalmanner - depressing the rate of secretion." @default.
- W2247121040 created "2016-06-24" @default.
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- W2247121040 date "1988-01-01" @default.
- W2247121040 modified "2023-09-27" @default.
- W2247121040 title "Uterine effects of inhibition of progesterone synthesis by a specific 3 B hydroxysteroid dehydrogenase inhibitor" @default.
- W2247121040 hasPublicationYear "1988" @default.
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