FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247131235> ?p ?o ?g. }

• W2247131235 endingPage "e0142098" @default.
• W2247131235 startingPage "e0142098" @default.
• W2247131235 abstract "We have previously shown that the nuclear receptor, NR1D1, is a cofactor in ApoA-IV-mediated downregulation of gluconeogenesis. Nuclear receptor, NR4A1, is involved in the transcriptional regulation of various genes involved in inflammation, apoptosis, and glucose metabolism. We investigated whether NR4A1 influences the effect of ApoA-IV on hepatic glucose metabolism. Our in situ proximity ligation assays and coimmunoprecipitation experiments indicated that ApoA-IV colocalized with NR4A1 in human liver (HepG2) and kidney (HEK-293) cell lines. The chromatin immunoprecipitation experiments and luciferase reporter assays indicated that the ApoA-IV and NR4A1 colocalized at the RORα response element of the human G6Pase promoter, reducing its transcriptional activity. Our RNA interference experiments showed that knocking down the expression of NR4A1 in primary mouse hepatocytes treated with ApoA-IV increased the expression of NR1D1, G6Pase, and PEPCK, and that knocking down NR1D1 expression increased the level of NR4A1. We also found that ApoA-IV induced the expression of endogenous NR4A1 in both cultured primary mouse hepatocytes and in the mouse liver, and decreased glucose production in primary mouse hepatocytes. Our findings showed that ApoA-IV colocalizes with NR4A1, which suppresses G6Pase and PEPCK gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose. The ApoA-IV-induced increase in NR4A1 expression in hepatocytes mediates further repression of gluconeogenesis. Our findings suggest that NR1D1 and NR4A1 serve similar or complementary functions in the ApoA-IV-mediated regulation of gluconeogenesis." @default.
• W2247131235 created "2016-06-24" @default.
• W2247131235 creator A5008316828 @default.
• W2247131235 creator A5020610670 @default.
• W2247131235 creator A5025618652 @default.
• W2247131235 creator A5029655107 @default.
• W2247131235 creator A5046202286 @default.
• W2247131235 creator A5084461414 @default.
• W2247131235 creator A5086529957 @default.
• W2247131235 date "2015-11-10" @default.
• W2247131235 modified "2023-10-17" @default.
• W2247131235 title "Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line" @default.
• W2247131235 cites W1574327030 @default.
• W2247131235 cites W1586220966 @default.
• W2247131235 cites W1602877814 @default.
• W2247131235 cites W1847582680 @default.
• W2247131235 cites W1967479888 @default.
• W2247131235 cites W1975191711 @default.
• W2247131235 cites W1976434307 @default.
• W2247131235 cites W1980655244 @default.
• W2247131235 cites W1981862471 @default.
• W2247131235 cites W1984695968 @default.
• W2247131235 cites W1995186432 @default.
• W2247131235 cites W2006046941 @default.
• W2247131235 cites W2006170285 @default.
• W2247131235 cites W2007663694 @default.
• W2247131235 cites W2023472561 @default.
• W2247131235 cites W2028548249 @default.
• W2247131235 cites W2035254458 @default.
• W2247131235 cites W2047919629 @default.
• W2247131235 cites W2050175422 @default.
• W2247131235 cites W2051636780 @default.
• W2247131235 cites W2051895634 @default.
• W2247131235 cites W2058294087 @default.
• W2247131235 cites W2059362512 @default.
• W2247131235 cites W2069436500 @default.
• W2247131235 cites W2074162351 @default.
• W2247131235 cites W2084099221 @default.
• W2247131235 cites W2100270286 @default.
• W2247131235 cites W2110453175 @default.
• W2247131235 cites W2113139156 @default.
• W2247131235 cites W2135084584 @default.
• W2247131235 cites W2137574569 @default.
• W2247131235 cites W2152546666 @default.
• W2247131235 cites W2331191058 @default.
• W2247131235 cites W2398870494 @default.
• W2247131235 doi "https://doi.org/10.1371/journal.pone.0142098" @default.
• W2247131235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4640595" @default.
• W2247131235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26556724" @default.
• W2247131235 hasPublicationYear "2015" @default.
• W2247131235 type Work @default.
• W2247131235 sameAs 2247131235 @default.
• W2247131235 citedByCount "15" @default.
• W2247131235 countsByYear W22471312352017 @default.
• W2247131235 countsByYear W22471312352018 @default.
• W2247131235 countsByYear W22471312352019 @default.
• W2247131235 countsByYear W22471312352020 @default.
• W2247131235 countsByYear W22471312352021 @default.
• W2247131235 countsByYear W22471312352022 @default.
• W2247131235 countsByYear W22471312352023 @default.
• W2247131235 crossrefType "journal-article" @default.
• W2247131235 hasAuthorship W2247131235A5008316828 @default.
• W2247131235 hasAuthorship W2247131235A5020610670 @default.
• W2247131235 hasAuthorship W2247131235A5025618652 @default.
• W2247131235 hasAuthorship W2247131235A5029655107 @default.
• W2247131235 hasAuthorship W2247131235A5046202286 @default.
• W2247131235 hasAuthorship W2247131235A5084461414 @default.
• W2247131235 hasAuthorship W2247131235A5086529957 @default.
• W2247131235 hasBestOaLocation W22471312351 @default.
• W2247131235 hasConcept C101762097 @default.
• W2247131235 hasConcept C104317684 @default.
• W2247131235 hasConcept C126322002 @default.
• W2247131235 hasConcept C127561419 @default.
• W2247131235 hasConcept C134018914 @default.
• W2247131235 hasConcept C134320426 @default.
• W2247131235 hasConcept C150194340 @default.
• W2247131235 hasConcept C153911025 @default.
• W2247131235 hasConcept C161733203 @default.
• W2247131235 hasConcept C185592680 @default.
• W2247131235 hasConcept C202751555 @default.
• W2247131235 hasConcept C20904676 @default.
• W2247131235 hasConcept C2776200302 @default.
• W2247131235 hasConcept C55493867 @default.
• W2247131235 hasConcept C62231903 @default.
• W2247131235 hasConcept C63932345 @default.
• W2247131235 hasConcept C71924100 @default.
• W2247131235 hasConcept C86339819 @default.
• W2247131235 hasConcept C86803240 @default.
• W2247131235 hasConcept C95444343 @default.
• W2247131235 hasConceptScore W2247131235C101762097 @default.
• W2247131235 hasConceptScore W2247131235C104317684 @default.
• W2247131235 hasConceptScore W2247131235C126322002 @default.
• W2247131235 hasConceptScore W2247131235C127561419 @default.
• W2247131235 hasConceptScore W2247131235C134018914 @default.
• W2247131235 hasConceptScore W2247131235C134320426 @default.
• W2247131235 hasConceptScore W2247131235C150194340 @default.
• W2247131235 hasConceptScore W2247131235C153911025 @default.
• W2247131235 hasConceptScore W2247131235C161733203 @default.

• next