Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247140192> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2247140192 endingPage "7" @default.
- W2247140192 startingPage "1321" @default.
- W2247140192 abstract "Unlike methacholine and histamine, ATP and uridine 5'-triphosphate (UTP) are more potent contractile agonists when they are applied to the mucosal (intraluminal, IL) surface of the guinea pig perfused trachea than when they are applied to the serosal (extraluminal, EL) surface. The relative contractile activities of a series of purine and pyrimidine compounds were assessed. The order of EL activity was: [2-methythio ATP (2 MeSATP) = adenosine 5'-diphosphate (ADP)] > [adenosine 5'-O-(2-thiodiphosphate) (ADP beta S) = ATP = adenosine 5'-O-(3-thiotriphosphate) (ATP gamma S)] > [(beta, gamma-imido ATP) (APPNP) = alpha, beta-methylene ATP (APCPP)] > [UTP = uridine 5'-diphosphate (UDP) = inosine 5'-triphosphate (ITP)] > [xanthosine 5'-triphosphate (XTP) beta, gamma-methylene ATP (APPCP)]. EL adenosine, adenosine 5'-monophosphate, uridine 5'-monophosphate and uridine were weak or inactive. The EL order of activity, therefore, shares some characteristics of P2Y receptors. The order of IL activity was: (ATP = UTP = ITP) > (ATP gamma S = ADP = APPNP = 2 MeSATP) > (UDP = ADP beta S = XTP) > APCPP; the other compounds were weak or inactive. The IL order of activity, therefore, resembled that for P2U or nucleotide receptors. ATP, APPNP, UTP, UDP, ITP and XTP were more active when added to the IL than after administration to the EL bath; the remaining compounds were similarly active EL and IL, or were more active EL than IL. Greater IL than EL activity of agonists was a property associated with preference for P2U-receptors.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2247140192 created "2016-06-24" @default.
- W2247140192 creator A5017712391 @default.
- W2247140192 creator A5064269241 @default.
- W2247140192 creator A5086773631 @default.
- W2247140192 date "1994-03-01" @default.
- W2247140192 modified "2023-09-23" @default.
- W2247140192 title "Contraction of the guinea pig isolated, perfused trachea to purine and pyrimidine agonists." @default.
- W2247140192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8138946" @default.
- W2247140192 hasPublicationYear "1994" @default.
- W2247140192 type Work @default.
- W2247140192 sameAs 2247140192 @default.
- W2247140192 citedByCount "5" @default.
- W2247140192 crossrefType "journal-article" @default.
- W2247140192 hasAuthorship W2247140192A5017712391 @default.
- W2247140192 hasAuthorship W2247140192A5064269241 @default.
- W2247140192 hasAuthorship W2247140192A5086773631 @default.
- W2247140192 hasConcept C104317684 @default.
- W2247140192 hasConcept C126322002 @default.
- W2247140192 hasConcept C160225129 @default.
- W2247140192 hasConcept C181199279 @default.
- W2247140192 hasConcept C185592680 @default.
- W2247140192 hasConcept C2776476023 @default.
- W2247140192 hasConcept C2776991684 @default.
- W2247140192 hasConcept C2777399203 @default.
- W2247140192 hasConcept C2778152042 @default.
- W2247140192 hasConcept C2778564976 @default.
- W2247140192 hasConcept C2779564974 @default.
- W2247140192 hasConcept C2781259782 @default.
- W2247140192 hasConcept C2993802102 @default.
- W2247140192 hasConcept C512185932 @default.
- W2247140192 hasConcept C55493867 @default.
- W2247140192 hasConcept C57306754 @default.
- W2247140192 hasConcept C67705224 @default.
- W2247140192 hasConcept C71924100 @default.
- W2247140192 hasConcept C86803240 @default.
- W2247140192 hasConcept C89560881 @default.
- W2247140192 hasConceptScore W2247140192C104317684 @default.
- W2247140192 hasConceptScore W2247140192C126322002 @default.
- W2247140192 hasConceptScore W2247140192C160225129 @default.
- W2247140192 hasConceptScore W2247140192C181199279 @default.
- W2247140192 hasConceptScore W2247140192C185592680 @default.
- W2247140192 hasConceptScore W2247140192C2776476023 @default.
- W2247140192 hasConceptScore W2247140192C2776991684 @default.
- W2247140192 hasConceptScore W2247140192C2777399203 @default.
- W2247140192 hasConceptScore W2247140192C2778152042 @default.
- W2247140192 hasConceptScore W2247140192C2778564976 @default.
- W2247140192 hasConceptScore W2247140192C2779564974 @default.
- W2247140192 hasConceptScore W2247140192C2781259782 @default.
- W2247140192 hasConceptScore W2247140192C2993802102 @default.
- W2247140192 hasConceptScore W2247140192C512185932 @default.
- W2247140192 hasConceptScore W2247140192C55493867 @default.
- W2247140192 hasConceptScore W2247140192C57306754 @default.
- W2247140192 hasConceptScore W2247140192C67705224 @default.
- W2247140192 hasConceptScore W2247140192C71924100 @default.
- W2247140192 hasConceptScore W2247140192C86803240 @default.
- W2247140192 hasConceptScore W2247140192C89560881 @default.
- W2247140192 hasIssue "3" @default.
- W2247140192 hasLocation W22471401921 @default.
- W2247140192 hasOpenAccess W2247140192 @default.
- W2247140192 hasPrimaryLocation W22471401921 @default.
- W2247140192 hasRelatedWork W1985992401 @default.
- W2247140192 hasRelatedWork W2000832714 @default.
- W2247140192 hasRelatedWork W2046892943 @default.
- W2247140192 hasRelatedWork W2053824931 @default.
- W2247140192 hasRelatedWork W2068285705 @default.
- W2247140192 hasRelatedWork W2131617947 @default.
- W2247140192 hasRelatedWork W2138660208 @default.
- W2247140192 hasRelatedWork W2247140192 @default.
- W2247140192 hasRelatedWork W2296872787 @default.
- W2247140192 hasRelatedWork W337576142 @default.
- W2247140192 hasVolume "268" @default.
- W2247140192 isParatext "false" @default.
- W2247140192 isRetracted "false" @default.
- W2247140192 magId "2247140192" @default.
- W2247140192 workType "article" @default.