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- W2247159525 abstract "OBJECTIVE: To study the prevalence, longitudinal course, and associations of depression in a cohort of ALS patients.BACKGROUND: Depression is a treatable complication of ALS. Depression may adversely affect survival in ALS.DESIGN/METHOD: PHQ9 (a validated depression instrument) and other self-reported measures were prospectively collected from ALS patients on tablet devices prior to their appointments at Cleveland Clinic using software developed in-house (Knowledge Program). Categorical data methods, logistic regression, and random effects models were used for analysis.RESULTS: Of 805 patients seen at Cleveland Clinic between 2007 and 2013, 713 patients had at least 1 PHQ9 measurement, and 393 had 2 or more PHQ9 measurements at least 30 days apart. Moderate (PHQ9 蠅10), moderately severe (PHQ9 蠅15) and severe depression (PHQ9蠅20) occurred in 43.5%, 20.1% and 8.1% of patients respectively. In patients with repeated measurements, a trend for worsening depression was not seen despite disease progression. Predictors of at least moderate depression in univariate analyses were female gender (unadjusted OR 1.46, p p p p -8 ), higher rate of decline of ALSFRS-R ( p p -5 ). Using stepwise logistic regression with multiple covariates, the only significant predictors of depression to emerge were initial ALSFRS-R and its rate of decline.CONCLUSIONS: Depression is prevalent in ALS and is associated with disease severity at initial assessment. Paradoxically however, worsening depression is not observed during follow-up despite disease progression. ALS patients who are female, older, have pseudobulbar affect, or respiratory onset of symptoms are more prone to depression and should be screened for early intervention. Disclosure: Dr. Thakore has nothing to disclose. Dr. Pioro has nothing to disclose." @default.
- W2247159525 created "2016-06-24" @default.
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- W2247159525 date "2014-04-08" @default.
- W2247159525 modified "2023-09-23" @default.
- W2247159525 title "Prevalence, Course And Associations Of Depression In ALS: Lack Of Worsening With Disease Progression. (S36.002)" @default.
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