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- W2247166131 abstract "In many fields of applications, test statistics are obtained by combining estimates from several experiments, studies or centres of a multi-centre trial. The commonly used test procedure to judge the evidence of a common overall effect can result in a considerable overestimation of the significance level, leading to a high rate of too liberal decisions. Alternative test statistics are presented and better approximating test distributions are derived. Explicitly discussed are the methods in the unbalanced heteroscedastic 1-way random ANOVA model and for the probability difference method, including interaction treatment by centres or studies. Numerical results are presented by simulation studies. In vielen Anwendungsgebieten werden Teststatistiken mittels Kombination von Schätzungen aus verschiedenen Experimenten, Studien oder Zentren einer multizentrischen Studie erhalten. Die allgemein verwandte Testmethode zur Beurteilung der Evidenz eines Gesamteffektes kann zu einer beträchtlichen Überschätzung des Signifikanz-Niveaus führen, mit der Folge eines hohen Anteils zu liberaler Entscheidungen. Es werden alternative Teststatistiken vorgestellt und besser approximierende Testverteilungen hergeleitet. Die Verfahren werden in der unbalancierten heteroskedastischen Einfachklassifikation der Varianzanalyse mit zufälligen Effekten und für die Wahrscheinlichkeits-Differenzen-Methode ausführlich diskutiert, unter Einbeziehung einer Wechselwirkung zwischen Behandlung und Zentren bzw. Studien. Numerische Ergebnisse werden aufgezeigt mittels Simulationsstudien." @default.
- W2247166131 created "2016-06-24" @default.
- W2247166131 creator A5058985726 @default.
- W2247166131 date "1999-12-01" @default.
- W2247166131 modified "2023-10-14" @default.
- W2247166131 title "An Alternative Method for Meta-Analysis" @default.
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- W2247166131 doi "https://doi.org/10.1002/(sici)1521-4036(199912)41:8<901::aid-bimj901>3.0.co;2-w" @default.
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