Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247228522> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2247228522 endingPage "F169" @default.
- W2247228522 startingPage "F164" @default.
- W2247228522 abstract "OKP cells express NHE-3, an amiloride-resistant Na+/H+ antiporter, which is likely an isoform responsible for apical proton secretion by the proximal tubule. We have previously shown that an amiloride-resistant Na+/H+ antiporter in OKP cells is regulated by dexamethasone, a synthetic glucocorticoid. The purpose of the present study was to examine the mechanism for the glucocorticoid-mediated increase in Na+/H+ antiporter activity. Incubation of OKP cells with 10(-6) M dexamethasone resulted in a two- to threefold increase in NHE-3 mRNA abundance. This increase was seen after 4 h of incubation with dexamethasone, a time course similar to that found for Na+/H+ antiporter activity. To examine the mechanism for the increase in NHE-3 mRNA abundance, mRNA half-life and in vitro transcription experiments were performed. NHE-3 mRNA had a half-life of 8 h in control and dexamethasone-treated cells. The rate of in vitro transcription was 1.8-fold greater when OKP cells were treated with dexamethasone. These data suggest that the glucocorticoid-mediated increase in Na+/H+ antiporter activity is due to an increase in NHE-3 gene transcription." @default.
- W2247228522 created "2016-06-24" @default.
- W2247228522 creator A5023488815 @default.
- W2247228522 creator A5035732349 @default.
- W2247228522 creator A5044587261 @default.
- W2247228522 creator A5066258545 @default.
- W2247228522 creator A5080913812 @default.
- W2247228522 date "1996-01-01" @default.
- W2247228522 modified "2023-10-15" @default.
- W2247228522 title "Glucocorticoids regulate NHE-3 transcription in OKP cells" @default.
- W2247228522 doi "https://doi.org/10.1152/ajprenal.1996.270.1.f164" @default.
- W2247228522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8769835" @default.
- W2247228522 hasPublicationYear "1996" @default.
- W2247228522 type Work @default.
- W2247228522 sameAs 2247228522 @default.
- W2247228522 citedByCount "21" @default.
- W2247228522 countsByYear W22472285222012 @default.
- W2247228522 countsByYear W22472285222013 @default.
- W2247228522 countsByYear W22472285222014 @default.
- W2247228522 countsByYear W22472285222022 @default.
- W2247228522 crossrefType "journal-article" @default.
- W2247228522 hasAuthorship W2247228522A5023488815 @default.
- W2247228522 hasAuthorship W2247228522A5035732349 @default.
- W2247228522 hasAuthorship W2247228522A5044587261 @default.
- W2247228522 hasAuthorship W2247228522A5066258545 @default.
- W2247228522 hasAuthorship W2247228522A5080913812 @default.
- W2247228522 hasConcept C104317684 @default.
- W2247228522 hasConcept C105580179 @default.
- W2247228522 hasConcept C114574056 @default.
- W2247228522 hasConcept C126322002 @default.
- W2247228522 hasConcept C134018914 @default.
- W2247228522 hasConcept C138885662 @default.
- W2247228522 hasConcept C153911025 @default.
- W2247228522 hasConcept C178790620 @default.
- W2247228522 hasConcept C179926584 @default.
- W2247228522 hasConcept C185592680 @default.
- W2247228522 hasConcept C202751555 @default.
- W2247228522 hasConcept C25642318 @default.
- W2247228522 hasConcept C2779608910 @default.
- W2247228522 hasConcept C2780401358 @default.
- W2247228522 hasConcept C2780841215 @default.
- W2247228522 hasConcept C41625074 @default.
- W2247228522 hasConcept C41895202 @default.
- W2247228522 hasConcept C537181965 @default.
- W2247228522 hasConcept C55493867 @default.
- W2247228522 hasConcept C57181701 @default.
- W2247228522 hasConcept C71924100 @default.
- W2247228522 hasConcept C86803240 @default.
- W2247228522 hasConceptScore W2247228522C104317684 @default.
- W2247228522 hasConceptScore W2247228522C105580179 @default.
- W2247228522 hasConceptScore W2247228522C114574056 @default.
- W2247228522 hasConceptScore W2247228522C126322002 @default.
- W2247228522 hasConceptScore W2247228522C134018914 @default.
- W2247228522 hasConceptScore W2247228522C138885662 @default.
- W2247228522 hasConceptScore W2247228522C153911025 @default.
- W2247228522 hasConceptScore W2247228522C178790620 @default.
- W2247228522 hasConceptScore W2247228522C179926584 @default.
- W2247228522 hasConceptScore W2247228522C185592680 @default.
- W2247228522 hasConceptScore W2247228522C202751555 @default.
- W2247228522 hasConceptScore W2247228522C25642318 @default.
- W2247228522 hasConceptScore W2247228522C2779608910 @default.
- W2247228522 hasConceptScore W2247228522C2780401358 @default.
- W2247228522 hasConceptScore W2247228522C2780841215 @default.
- W2247228522 hasConceptScore W2247228522C41625074 @default.
- W2247228522 hasConceptScore W2247228522C41895202 @default.
- W2247228522 hasConceptScore W2247228522C537181965 @default.
- W2247228522 hasConceptScore W2247228522C55493867 @default.
- W2247228522 hasConceptScore W2247228522C57181701 @default.
- W2247228522 hasConceptScore W2247228522C71924100 @default.
- W2247228522 hasConceptScore W2247228522C86803240 @default.
- W2247228522 hasIssue "1" @default.
- W2247228522 hasLocation W22472285221 @default.
- W2247228522 hasLocation W22472285222 @default.
- W2247228522 hasOpenAccess W2247228522 @default.
- W2247228522 hasPrimaryLocation W22472285221 @default.
- W2247228522 hasRelatedWork W1494139209 @default.
- W2247228522 hasRelatedWork W1964197368 @default.
- W2247228522 hasRelatedWork W2042294891 @default.
- W2247228522 hasRelatedWork W2044790044 @default.
- W2247228522 hasRelatedWork W2088687690 @default.
- W2247228522 hasRelatedWork W2089675043 @default.
- W2247228522 hasRelatedWork W2400443698 @default.
- W2247228522 hasRelatedWork W2409395677 @default.
- W2247228522 hasRelatedWork W2461564378 @default.
- W2247228522 hasRelatedWork W2410120624 @default.
- W2247228522 hasVolume "270" @default.
- W2247228522 isParatext "false" @default.
- W2247228522 isRetracted "false" @default.
- W2247228522 magId "2247228522" @default.
- W2247228522 workType "article" @default.