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- W2247282336 abstract "Soluble guanylyl cyclase (sGC) is associated to endothelial barrier dysfunction and inflammatory reaction during acute pancreatitis. Thus, sGC/cGMP inhibition using methylene blue (MB) was investigated. Acute necrotizing pancreatitis was induced by retrograde infusion of sodium taurocholate 5% (1mL/kg) and enterokinase (8U/kg) in the pig pancreatic duct. Pigs were allocated in 4 groups (n=5): 1: control; 2: pancreatitis; 3: MB infusion post pancreatitis; and 4: MB infusion pre pancreatitis. Data underwent Two and One Way Analysis of Variance (ANOVA) followed by Tukey test with p<0.05. Hemodynamic changes begin 3 h after pancreatitis onset and exhibited mild alterations for either MB administrations. Plasma and ascitic amylase and lipase levels were greatly increased in groups 2, 3 and 4. Plasma nitric oxide (NO) was unaltered. Intra-abdominal fluid collection had a 15-fold volume increase on group 2. Groups 3 and 4 had less fluid accumulation. Preemptive MB was associated to 50% more free radical injury. For post-treatment, neutrophil in pancreatic tissue had a 2-fold increase. In summary, sGC inhibition by MB clinically did not affect hemodynamic pattern due to a non-pivotal role of NO on this investigation. Moreover, early and late sGC inhibition may worsen free radical damage and magnitude of inflammatory process, respectively. Support: CAPES; FAEPA-HC/FMRP." @default.
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- W2247282336 date "2009-04-01" @default.
- W2247282336 modified "2023-10-09" @default.
- W2247282336 title "Acute necrotizing pancreatitis shock and the sGC/cGMP system: methylene blue use as pharmacological tool" @default.
- W2247282336 doi "https://doi.org/10.1096/fasebj.23.1_supplement.794.11" @default.
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