Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247290283> ?p ?o ?g. }
- W2247290283 endingPage "74" @default.
- W2247290283 startingPage "67" @default.
- W2247290283 abstract "Morbidity and mortality are massively increased in patients with chronic kidney disease (CKD) and patients with end-stage renale disease (ESRD). Bone disease (renal osteodystrophy) and vascular disease (accelerated arteriosclerosis) are two typical entities contributing to this excess morbidity and mortality. Vitamin K and vitamin K-dependent-proteins play pivotal roles in the physiology of mineralization and in preventing ectopic calcification: two of these vitamin K-dependent-proteins are osteocalcin (regulating bone mineralization) and matrix-Gla protein (MGP, local calcification inhibitor in the vessel wall). Vitamin K deficiency impairs the physiological function of osteocalcin and MGP and, therefore, presumably contributes to bone demineralisation and vascular calcification (the so-called calcification paradox). In this context, the usage of vitamin K antagonists for long-term oral anticoagulation therapy might be risky especially in CKD patients exhibiting a high background level of vascular calcification. We present a summary of data describing the potential role of vitamin K deficiency and supplementation in bone and vascular disease in patients with CKD or ESRD." @default.
- W2247290283 created "2016-06-24" @default.
- W2247290283 creator A5016480765 @default.
- W2247290283 creator A5027966081 @default.
- W2247290283 creator A5035879928 @default.
- W2247290283 creator A5070811893 @default.
- W2247290283 date "2009-02-01" @default.
- W2247290283 modified "2023-09-25" @default.
- W2247290283 title "Coagulation Meets Calcification: The Vitamin K System" @default.
- W2247290283 cites W1735160523 @default.
- W2247290283 cites W1828902039 @default.
- W2247290283 cites W1857537301 @default.
- W2247290283 cites W1934483098 @default.
- W2247290283 cites W1943570713 @default.
- W2247290283 cites W1964171224 @default.
- W2247290283 cites W1968985960 @default.
- W2247290283 cites W1981228902 @default.
- W2247290283 cites W1986479537 @default.
- W2247290283 cites W1990123370 @default.
- W2247290283 cites W1991055135 @default.
- W2247290283 cites W2001994991 @default.
- W2247290283 cites W2006291120 @default.
- W2247290283 cites W2015677761 @default.
- W2247290283 cites W2021800013 @default.
- W2247290283 cites W2023653442 @default.
- W2247290283 cites W2030805566 @default.
- W2247290283 cites W2035221187 @default.
- W2247290283 cites W2045847718 @default.
- W2247290283 cites W2047544573 @default.
- W2247290283 cites W2047777477 @default.
- W2247290283 cites W2058579856 @default.
- W2247290283 cites W2061922416 @default.
- W2247290283 cites W2063151587 @default.
- W2247290283 cites W2064239411 @default.
- W2247290283 cites W2068677249 @default.
- W2247290283 cites W2079319424 @default.
- W2247290283 cites W2084789695 @default.
- W2247290283 cites W2088747704 @default.
- W2247290283 cites W2096024580 @default.
- W2247290283 cites W2096837196 @default.
- W2247290283 cites W2108141317 @default.
- W2247290283 cites W2110601215 @default.
- W2247290283 cites W2113985697 @default.
- W2247290283 cites W2115431937 @default.
- W2247290283 cites W2124364682 @default.
- W2247290283 cites W2134132325 @default.
- W2247290283 cites W2134487085 @default.
- W2247290283 cites W2136511302 @default.
- W2247290283 cites W2137920226 @default.
- W2247290283 cites W2144461421 @default.
- W2247290283 cites W2148912722 @default.
- W2247290283 cites W2165853103 @default.
- W2247290283 cites W2171303601 @default.
- W2247290283 cites W2171751430 @default.
- W2247290283 cites W2313705116 @default.
- W2247290283 cites W4376848475 @default.
- W2247290283 doi "https://doi.org/10.1177/039139880903200202" @default.
- W2247290283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19363777" @default.
- W2247290283 hasPublicationYear "2009" @default.
- W2247290283 type Work @default.
- W2247290283 sameAs 2247290283 @default.
- W2247290283 citedByCount "57" @default.
- W2247290283 countsByYear W22472902832012 @default.
- W2247290283 countsByYear W22472902832013 @default.
- W2247290283 countsByYear W22472902832014 @default.
- W2247290283 countsByYear W22472902832015 @default.
- W2247290283 countsByYear W22472902832016 @default.
- W2247290283 countsByYear W22472902832017 @default.
- W2247290283 countsByYear W22472902832018 @default.
- W2247290283 countsByYear W22472902832019 @default.
- W2247290283 countsByYear W22472902832020 @default.
- W2247290283 countsByYear W22472902832021 @default.
- W2247290283 countsByYear W22472902832023 @default.
- W2247290283 crossrefType "journal-article" @default.
- W2247290283 hasAuthorship W2247290283A5016480765 @default.
- W2247290283 hasAuthorship W2247290283A5027966081 @default.
- W2247290283 hasAuthorship W2247290283A5035879928 @default.
- W2247290283 hasAuthorship W2247290283A5070811893 @default.
- W2247290283 hasConcept C124490489 @default.
- W2247290283 hasConcept C126322002 @default.
- W2247290283 hasConcept C131075544 @default.
- W2247290283 hasConcept C134018914 @default.
- W2247290283 hasConcept C160160445 @default.
- W2247290283 hasConcept C181199279 @default.
- W2247290283 hasConcept C185592680 @default.
- W2247290283 hasConcept C2776169692 @default.
- W2247290283 hasConcept C2776489590 @default.
- W2247290283 hasConcept C2776541429 @default.
- W2247290283 hasConcept C2776556354 @default.
- W2247290283 hasConcept C2776699218 @default.
- W2247290283 hasConcept C2776940978 @default.
- W2247290283 hasConcept C2778653478 @default.
- W2247290283 hasConcept C2780309369 @default.
- W2247290283 hasConcept C2780814755 @default.
- W2247290283 hasConcept C2781037820 @default.
- W2247290283 hasConcept C3951539 @default.
- W2247290283 hasConcept C55493867 @default.
- W2247290283 hasConcept C71924100 @default.